The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects
Figure 6
Overexpression of c-Met receptor in lung fibroblasts restores effects of rosiglitazone on MMP-1 (a) and collagen type I (b) in black lung fibroblasts. (a) Each bar represents the mean ± SD of duplicate determinations in four independent experiments. *Statistically significant differences between cells stimulated with rosiglitazone versus nonstimulated cells (). (b) Representative immunoblots from 3 independent experiments performed with 5 white and 5 black cell lines are presented. Anti-β-actin antibody was used as the sample loading control.
