Table 3: Various intrapleural fibrinolytics (Adapted from Colice et al. [7]).

FibrinolyticDoseInstillationDuration

Streptokinase250,000 IU100–200 cc NSQD for up to 7 days
Urokinase10,000 IU100 cc NSQD for up to 3 days
t-PA10–25 mg100 cc NSBID for up to 5 days

t-PA: tissue plasminogen activator.
IU: international units.
NS: normal saline.
QD: every day.
BID: twice a day.