Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis

Table 5

Correlation of apoptotic markers’ expression with respiratory function parameters before and after treatment in patients with IPF.

Before treatment		FVC	FVC%	FEV1	FEV1%	FEV1/FVC	DLCO	DLCO%	aFVC	aFVC%	aFEV1	aFEV1%	aFEV1/FVC	aDLCO	aDLCO%
ApoptAg (+) cells	Pearson	,010	−,215	,021	−,190	−,104	,046	,066	−,060	−,212	−,027	−,192	,139	−,219	−,234
	P	,966	,377	,931	,436	,672	,875	,821	,812	,398	,916	,446	,583	,473	,441
Apopt Ag area	Pearson	,021	−,206	,046	−,247	,134	−,377	−,340	−,069	−,236	−,002	−,242	,259	−,300	−,439
	P	,942	,460	,871	,374	,634	,283	,337	,806	,397	,994	,384	,351	,343	,153
ApoptAg density	Pearson	−,052	,177	,019	,240	,427	,042	,188	−,243	−,187	−,238	−,330	,348	−,517	−,538
	P	,854	,529	,947	,390	,113	,908	,602	,383	,504	,393	,230	,204	,086	,071
Bcl-2 (+) cells	Pearson	,388	,168	,365	,082	−,279	,204	,089	,449	,334	,462	,281	−,387	,557	,451
	P	,091	,479	,113	,730	,233	,466	,751	,054	,162	,046	,245	,102	,039	,106
Bcl-2 density	Pearson	−,196	−,082	−,215	−,071	,144	−,086	-,015	−,058	,075	−,048	,105	,188	−,439	−,421
	P	,467	,762	,425	,794	,594	,780	,961	,838	,792	,866	,709	,502	,204	,226
Bax (+) cells	Pearson	,039	−,199	−,086	−,314	−,643	,314	,265	,105	−,021	−,015	−,125	−,330	−,066	−,024
	P	,872	,401	,718	,178	,002	,255	,340	,667	,932	,951	,611	,168	,823	,936
Bax density	Pearson	−,072	−,257	−,125	−,379	,269	−,329	−,247	,183	,109	,198	,060	−,078	−,435	−,368
	P	,790	,337	,646	,148	,314	,250	,395	,513	,699	,479	,832	,781	,182	,266
Fas (+) cells	Pearson	,040	−,180	,070	−,217	−,268	,234	,241	,037	,000	,103	,044	−,011	,119	,157
	P	,866	,448	,769	,359	,254	,402	,386	,879	,999	,674	,857	,965	,686	,591
Fas density	Pearson	−,303	−,109	−,324	−,018	−,025	,258	,317	−,243	−,047	−,327	,009	,001	,124	,229
	P	,254	,688	,221	,947	,926	,395	,291	,383	,867	,234	,974	,997	,732	,524
Fasl (+) cells	Pearson	−,153	−,369	−,176	−,310	−,385	,073	,050	−,230	−,357	−,283	−,309	,089	−,081	−,028
	P	,520	,110	,459	,184	,094	,796	,861	,343	,133	,240	,198	,718	,782	,924
Fasl density	Pearson	,195	,172	,223	,195	−,077	,215	,152	,102	,053	,072	−,021	−,171	,548	,431
	P	,486	,541	,424	,487	,784	,501	,637	,729	,858	,807	,942	,558	,127	,247

𝑃<0.05 : statistically significant.
FVC: forced vital capacity, FEV1: forced expiratory volume in one second, DLCO: diffusing capacity for carbon monoxide, a: after six months of treatment.