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Pulmonary Medicine
Volume 2013, Article ID 618576, 9 pages
Research Article

Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques

1Nemours Research Lung Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA
2Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA
3Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
4Division of Neonatology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
5Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107, USA

Received 31 December 2012; Revised 6 March 2013; Accepted 7 March 2013

Academic Editor: S. L. Johnston

Copyright © 2013 Elena Rodriguez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements. Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways). The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.