Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance
Table 3
Impulse oscillometry parameters.
Controls
GOLD1
GOLD2
GOLD3
GOLD4
, kPa*/L
0.27 (0.23–0.32)
0.29 (0.26–0.31)
0.37 (0.30–0.44)***†
0.50 (0.39–0.67)***†††‡‡
0.52 (0.41–0.70)***†††‡‡‡
%p
90 (68–91)
83 (74–97)
105 (90–120)***†
136 (121–195)***†††‡‡‡
134 (126–173)***†††‡‡‡
, kPa*/L
0.21 (0.18–0.26)
0.22 (0.19–0.27)
0.26 (0.20–0.28)
0.30 (0.24–0.38)***††‡
0.28 (0.25–0.34)**†
%p
70 (62–89)
79 (64–86)
81 (73–96)*
104 (85–130)***†††‡‡
89 (79–99)**†
, kPa*/L
0.04 (0.03–0.08)
0.07 (0.03–0.10)
0.12 (0.06–0.15)***†
0.17 (0.12–0.33)***†††‡‡
0.24 (0.17–0.36)***†††‡‡‡
%p
100 (67–150)
167 (75–192)
250 (131–306)***†
388 (281–554)***†††‡‡
425 (367–650)***†††‡‡‡
AX, kPa*/L
0.18 (0.13–0.44)
0.16 (0.11–0.57)
0.69 (0.34–1.49)***††
1.64 (0.97–3.61)***†††‡‡
3.17 (1.46–3.54)***†††‡‡‡
, Hz
10.5 (8.9–14.6)
12.5 (9.1–15.5)
16.4 (13.9–19.9)***††
20.4 (18.2–25.3)***†††‡
23.9 (21.3–27.7)***†††‡‡‡#
X5, kPa*/L
−0.09 (−0.11–−0.07)
−0.08 (−0.12–−0.06)
−0.14 (−0.22–−0.10)**†
−0.25 (−0.43–−0.16)***†††‡‡
−0.42 (−0.49–−0.23)***†††‡‡‡
X5 %p
199 (104–312)
175 (145–263)
389 (182 –541)***†
494 (447–795)***†††
677 (501–859)***†††‡‡
Significant difference compared to healthy smokers, significant difference compared to GOLD1, significant difference compared to GOLD2, significant difference compared to GOLD3, one symbol flagging P < 0.05, two symbols flagging P < 0.01 and three symbols flagging P < 0.001. All data are presented as median (interquartile range).
