Sleep Disordered Breathing in Children with Mitochondrial Disease
Table 1
Patient demographics, allergic rhinitis history, adenotonsillar history, and neuromuscular tone characteristics in patients with mitochondrial disorder.
ID
Gender
Age (years) at PSG
Race/ethnicity
BMI in kg/m2 (percentile)
Allergic rhinitis by history
Tonsil & adenoid history
NM Tone
Spirometry
1
F
9
W NH
17.2 (50–75%)
Y
2+
Normal
Mixed
2
M
6
W NH
15.5 (75%)
N
N
Normal
Normal
3
M
3
W NH
13.3 (90%)
N
4+, A
Hypotonia
Normal
5
M
2
W NH
12.3 (<3%)
Y
3+
Normal
—
6
F
12
W NH
26.8 (95–97%)
Y
T & A
Hypotonia
Normal
7
M
16
W NH
23.7 (75–85%)
Y
N
Hypotonia
Normal
8
M
10
W NH
18.7 (75%)
N
T & A
Normal
—
9
M
2
W NH
19.4 (>97%)
N
N
Hypertonia
—
10
F
2
W NH
15.4 (25%)
N
Y
Hypotonia
—
11
M
5
W NH
14.2 (10%)
N
Y
Normal
Normal
12
M
7
W NH
29.6 (>97%)
N
N
Hypotonia
Normal
13
F
5
W Hispanic
22.0 (>97%)
N
T & A
Hypotonia
Normal
14
M
1.5
W NH
18.8
N
N
Severe hypotonia
—
15
F
3.5
W NH
15.7 (50%)
N
N
Hypertonia
—
16
F
2
W Hispanic
16.3 (50%)
N
N
Hypertonia with cogwheel
—
17
M
16
W NH
15.8 (<3%)
N
N
Normal
—
18
M
18
W NH
22.5 (50%)
N
N
Hypotonia
Restrictive
19
F
11
W NH
18.0 (50%)
Y
N
Hypotonia
Normal
PSG: polysomnogram, W: white, NH: non-Hispanic, H: Hispanic, BMI: body mass index, T & A: posttonsillectomy, A: postadenoidectomy, NM: neuromuscular, MD: mitochondrial disorder, Y: yes, N: no or none, and ESS: Epworth sleepiness scale.
