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Pulmonary Medicine
Volume 2014, Article ID 581738, 11 pages
Research Article

Effects of Inactivated Bordetella pertussis on Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats

1Zhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China
2Clinical College of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, China
3First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou 310000, China
4Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310005, China
5Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Received 28 February 2014; Accepted 17 June 2014; Published 9 July 2014

Academic Editor: Andrew Sandford

Copyright © 2014 Ya-Juan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper indicated that inactivated Bordetella pertussis (iBp) can enhance the lung airway hyperreactivity of the rats sensitized and challenged with OVA. The mechanisms were involved in the upregulation of cAMP-PDE activity and PDE4A, PDE4D, and PDE3 gene expression in the lungs. But only PDE4 activity was different between the OVA and OVA+iBp groups, and PDE4D expression was significantly increased in iBp rats alone. So, our data suggested that cosensitization with OVA and iBp affects lung airway reactivity by modulating the lung cAMP-PDE activity and PDE4D gene expression.