Review Article
Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
Table 2
Contraindications to LTX.
(a) Absolute contraindications to LTX |
| (i) Malignant diseases in the past 2 years | | (ii) Untreatable severe dysfunction of another important organ system (heart, liver, and kidney) not amenable to surgical correction/combined TX | | (iii) Chronic, incurable extrapulmonary infection | | (iv) Severe deformations of chest and spine | | (v) Severe or symptomatic osteoporosis | | (vi) Lack of adherence to therapy | | (vii) Untreatable mental disorders combined with lack of cooperation | | (viii) Addictive disorder currently or during the past 6 months (tobacco and alcohol addiction, substance abuse) | |
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(b) Relative contraindications to LTX |
| (i) Age > 65 years | | (ii) Critical/unstable clinical situation | | (iii) Seriously limited functional status without potential for rehabilitation | | (iv) Colonisation with Burkholderia cenocepacia, Burkholderia gladioli and Mycobacteria abscessus | | (v) Diseases not optimally treated (e.g., arterial hypertension, diabetes mellitus, GERD, osteoporosis, and coronary heart disease) | |
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