Statins in Asthma: Potential Beneficial Effects and Limitations

Table 2

Summary of prospective clinical trials and their results used in our review.

Study name	Study type	Statin used	Dose used (mg per day)	Study sample	Statin usage duration	Results; (i) Pulmonary function results; (ii) Airway and serum inflammation; (iii) Asthma symptoms; (iv) Acute exacerbations
Braganza et al. [112]	RCT	Atorvastatin	40	71	4 weeks	(i) No significant difference; (ii) No significant difference; (iii) ACQ and AQLQ increased; (iv) Not measured
Menzies et al. [113]	RCT	Simvastatin	20, 40	16	4 weeks	(i) No significant difference; (ii) 0.86 geometric mean fold decrease in FENO; (iii) Not measured; (iv) Not measured
Hothersall et al. [114]	RCT	Atorvastatin	40	54	8 weeks	(i) No significant difference; (ii) Macrophage count and sputum fluid leukotriene B4 decreased; (iii) No significant difference; (iv) Not measured
Cowan et al. [115]	RCT	Simvastatin	40	43	4 weeks	(i) PEF, FEV1 increased; (ii) Sputum eosinophils decreased; (iii) ACQ decreased; (iv) Not measured
Foumani et al. [116]	RCT	Atorvastatin	40	67	8 weeks	(i) No significant difference; (ii) Not measured; (iii) Not measured; (iv) Not measured
Fahimi et al. [117]	RCT	Atorvastatin	10	17	4 weeks	(i) No significant difference; (ii) Not measured; (iii) Not measured; (iv) Morbidity decreased
Feschenko et al. [118]	RCT	Atorvastatin (along with ICS and salbutamol)	40	31	4 weeks	(i) Morning PEF, FEV1 increased; (ii) Not measured; (iii) Not measured; (iv) Night symptoms, cough, daily symptoms, and use of salbutamol decreased
Moini et al. [119]	RCT	Atorvastatin	40	62	8 weeks	(i) No significant difference; (ii) Not measured; (iii) Not measured; (iv) Not measured
Maneechotesuwan et al. [120]	RCT	Simvastatin	10	47	8 weeks	(i) No significant difference; (ii) Sputum eosinophils reduced; (iii) Not measured; (iv) Not measured

RCT: randomized controlled trial. AQLQ: Asthma Quality of Life Questionnaire.
FEV1: forced expiratory volume in 1st second. PEF: peak expiratory flow.
ACQ: Asthma Control Questionnaire. FENO: fractional exhaled nitric oxide