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Pulmonary Medicine
Volume 2016, Article ID 1643717, 5 pages
Research Article

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

1Department of Biochemistry, Parul Institute of Medical Science and Research (PIMSR), Limda, Waghodia, Gujarat 391760, India
2Department of Biochemistry, C.U. Shah Medical Collage, Surendranagar, Gujarat, India
3Department of Biochemistry, S.B.K.S MI & RC, Piparia, Vadodara, Gujarat 391760, India
4Department of Biochemistry, Pramukhswami Medical College, Karamsad, Gujarat, India

Received 5 July 2016; Accepted 25 September 2016

Academic Editor: Andrew Sandford

Copyright © 2016 Mohammed Nadeem Shaikh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma. Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects. Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that. Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.