Clinical Study

Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study

Table 3

Saccharin test times.

TreatmentMean (SD) and median (minimum to maximum)
BaselineSame day but after NHFNext day, after NHF

NHF 37C 11 ()6 ()4 ()
3 (0 to 45)5 (3 to 18)3 (0 to 9)

NHF 41C8 ()4 ()12 ()
5 (0 to 43)4 (0 to 10)5 (0 to 45)

Times are in minutes. NHF = nasal high flow.
, with the following exceptions:
For one of the participants, the baseline saccharin prior to “NHF 37C” was not tasted within 45 minutes; all of their other test times were normal.
For one of the participants, the next day saccharin after “NHF 41C” was not tasted within 45 minutes; all of their other test times were normal.
The data points for when saccharin was not tasted within 45 minutes were assigned a value of 45 minutes.
One participant had abnormal saccharin taste times (>20 minutes, but under 45 minutes) for both baseline tests and for the “day after” test following “NHF 41C” but normal results directly after both “NHF 37C” and “NHF 41C.”
The other seven participants had normal baseline, “same day,” and “next day” measurement times (≤20 minutes).