Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria
Table 2
TERT, OGG1, and CHRNA5 genotypes and lung cancer risk.
Genes
Genotype/modea
Cases (%)
Controls (%)
OR (CI)
TERT rs2853669
126
94
TT
71 (56.3)
57 (61)
Ref
—
—
TC
49 (38.9)
36 (38)
0.755
0.99 (0.53–1.89)
0.99
CC
6 (4,8)
1 (1)
0.11
4.15 (0.61–83.73)
0.21
T
191 (76)
150 (80)
Ref
—
—
C
61 (24)
38 (20)
1.22 (0.72–2.07)
0.45
Recessive
0.12
4.72 (0.68–97.04)
0.17
Dominant
0.52
1.11 (0.59–2.07)
0.75
CHRNA5b rs16969968
143
211
GG
60 (42)
93 (44.3)
Ref
—
—
GA
64 (44.8)
105 (49.8)
0.8
0.98 (0.58–1.63)
0.93
AA
19 (13.2)
13 (6.2)
0.03
1.75 (0.68–4.69)
0.25
G
184 (64.3)
291 (69)
Ref
—
—
A
102 (35.7)
131 (31)
1.16 (0.80–1.68)
0.41
Recessive
0.02
1.83 (0.78–4.48)
0.16
Dominant
0.69
1.07 (0.65–1.76)
0.78
OGG1b rs1052133
144
210
CC
79 (54.9)
107 (50.9)
Ref
—
—
CG
54 (37.5)
83 (39.3)
0.58
0.88 (0.52–1.48)
0.62
GG
11 (7.6)
20 (9.5)
0.46
1.45 (0.53–4.07)
0.46
C
212 (73.6)
297 (71)
Ref
—
—
G
76 (26.4)
123 (29)
1.01 (0.68–1.5)
0.92
Recessive
0.53
1.44 (0.55–3.83)
0.45
Dominant
0.46
0.94 (0.57–1.54)
0.79
OR = odds ratio; CI = confidence interval. OR adjusted for sex age and tobacco consumption. aThe dominant mode: AA vs Aa+aa, where A is major allele and a is minor allele; the recessive mode: AA+Aa vs aa. bNumbers may not add up total number of patients due to genotype failures.
