Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria
Table 3
Association between TERT, CHRNA5, and OGG1 polymorphisms and lung cancer risk, stratified by histology and tobacco consumption.
Population
Gene
Genotype
Cases/controlsa
ORAdj
CIAdj
Adj
Smokers
TERT rs2853669
TT
46/20
Ref
TC
40/19
0.81
0.86
(0.39-188)
0.71
CC
5/0
0.14
—
—
0.99
Dominant (TC+CC)
46/20
0.93
0.97
(0.44-2.10)
0.94
Recessive (TC+TT)
86/39
0.13
—
—
0.98
CHRNA5 rs16969968
GG
42/24
Ref
GA
44/34
0.37
0.72
(0.36-1.42)
0.35
AA
18/3
0.05
3.29
(0.79-15.28)
0.08
Dominant (GA+AA)
62/37
0.89
0.93
(0.48-1.79)
0.83
Recessive (GA+GG)
86/58
0.02
3.91
(1.24-17.34)
0.03
OGG1 rs1052133
CC
59/35
Ref
CG
36/23
0.82
0.81
(0.40-1.63)
0.56
GG
9/3
0.40
2.01
(0.53-9.80)
0.32
Dominant (CG+GG)
45/26
0.93
0.92
(0.48-1.78)
0.82
Recessive (CG+CC)
95/58
0.37
2.03
(0.57-9.59)
0.30
Nonsmokers
TERT rs2853669
TT
23/30
Ref
TC
9/9
0.62
1.32
(0.42-4.19)
0.63
CC
1/1
0.85
1.54
(0.05-41.59)
0.76
Dominant (TC+CC)
10/10
0.61
1.38
(0.46-4.17)
0.55
Recessive (TC+TT)
32/39
0.89
1.71
(0.06-47.92)
0.71
CHRNA5 rs16969968
GG
16/49
Ref
GA
22/44
0.4
1.36
(0.61-3.05)
0.44
AA
1/7
0.44
0.33
(0.01-2.49)
0.36
Dominant (GA+AA)
21/51
0.54
1.19
(0.54-2.63)
0.65
Recessive (GA+GG)
36/93
0.34
0.31
(0.01-1.97)
0.29
OGG1 rs1052133
CC
18/48
Ref
CG
18/45
0.86
0.94
(0.42-2.10)
0.89
GG
2/7
0.74
0.83
(0.10 - 4.23)
0.84
Dominant
20/52
0.94
0.91
(0.42-1.99)
0.82
Recessive
36/93
0.71
0.84
(0.11-3.80)
0.83
Adenocarcinoma
TERT rs2853669
TT
50/57
Ref
TC
33/36
0.88
1.01
(0.50-2)
0.97
CC
3/1
0.26
3.39
(0.39-72.50)
0.31
Dominant (TC+CC)
36/37
0.73
1.09
(0.55-2.13)
0.79
Recessive (TC+TT)
83/93
0.27
3.90
(0.43-85.93)
0.26
CHRNA5 rs16969968
GG
37/93
Ref
GA
42/105
0.98
1.01
(0.57-1.79)
0.95
AA
16/13
0.005
2.54
(0.95-7.07)
0.06
Dominant (GA+AA)
58/118
0.40
1.18
(0.68-2.06)
0.53
Recessive (GA+GG)
79/198
0.003
2.55
(1.07-6.35)
0.03
OGG1 rs1052133
CC
50/107
Ref
CG
39/83
0.98
0.95
(0.53-1.67)
0.86
GG
7/20
0.53
1.61
(0.52-4.80)
0.39
Dominant (CG+GG)
46/103
0.85
1.00
(0.58-1.73)
0.97
Recessive (CG+CC)
89/190
0.52
1.49
(0.50-4.24)
0.45
Squamous
TERT rs2853669
TT
21/57
Ref
TC
16/36
0.63
1.10
(0.43-2.77)
0.83
CC
3/1
0.03
10.87
(0.67-573.04)
0.15
Dominant (TC+CC)
19/37
0.38
1.26
(0.51-3.12)
0.60
Recessive (TC+TT)
37/93
0.04
7.60
(0.65-208.01)
0.14
CHRNA5 rs16969968
GG
23/93
Ref
GA
22/105
0.61
0.81
(0.37-1.71)
0.58
AA
3/13
0.91
0.78
(0.13-3.71)
0.76
Dominant (GA+AA)
25/118
0.62
0.80
(0.38-1.68)
0.56
Recessive (GA+GG)
45/198
0.98
0.93
(0.18-3.95)
0.93
OGG1 rs1052133
CC
29/107
Ref
CG
15/83
0.24
0.64
(0.28-1.42)
0.28
GG
4/20
0.60
1.50
(0.31-6.72)
0.59
Dominant (CG+GG)
19/103
0.23
0.71
(0.33-1.52)
0.39
Recessive (CG+CC)
44/190
0.79
1.67
(0.38-6.66)
0.46
OR = odds ratio; CI = confidence interval; Adj = adjusted. OR adjusted for gender and age. OR adjusted for gender, age, and smoking habit. aNumbers may not add up the total number of patients due to genotype failures.
