Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria

Table 5

Association between TERT, CHRNA5, and OGG1 polymorphisms and lung cancer risk, stratified by gender, age, smoking, and histological at the level of alleles.

Population	Gene	Allele	Case/control^a	p	ORAdj	CIAdj	Adj
Smokers	TERT	T	132/59
		C	50/19	0.60	1.15	0.62–2.18	0.66
	CHRNA5	G	128/82
		A	80/40	0.30	1.25	0.78–2.03	0.34
	OGG1	C	154/93
		G	54/29	0.65	1.07	0.64–1.83	0.79
Nonsmokers	TERT	T	55/69
		C	11/11	0.62	1.36	0.52–3.54	0.52
	CHRNA5	G	52/142
		A	22/58	0.91	0.98	0.53–1.78	0.95
	OGG1	C	54/141
		G	22/59	0.93	0.92	0.50–1.67	0.81
Adenocarcinoma	TERT	T	131/128
		C	39/30	0.38	1.16	0.66–2.04	0.57
	CHRNA5	G	114/224
		A	74/98	0.04	1.33	0.89–1.98	0.15
	OGG1	C	137/234
		G	53/88	0.88	1.07	0.69–1.63	0.75
Squamous	TERT	T	56/128
		C	22/30	0.11	1.48	0.71–3.08	0.28
	CHRNA5	G	66/224
		A	28/98	0.90	0.87	0.49–1.52	0.64
	OGG1	C	71/234
		G	23/88	0.58	0.88	0.48–1.60	0.70
Male	TERT	T	146/90
		C	52/24	0.30	1.15	0.64–2.11	0.63
	CHRNA5	G	145/123
		A	87/57	0.21	1.21	0.78–1.87	0.38
	OGG1	C	175/133
		G	60/47	0.91	0.98	0.61–1.57	0.93
Female	TERT	T	41/38
		C	9/6	0.56	1.45	0.47–4.76	0.51
	CHRNA5	G	35/101
		A	15/41	0.88	0.99	0.47–2.02	0.98
	OGG1	C	34/101
		G	16/41	0.68	1.07	0.51–2.16	0.85
>60	TERT	T	92/37
		C	34/5	0.04	2.21	0.84–6.96	0.13
	CHRNA5	G	91/53
		A	53/27	0.65	1.12	0.63–2.03	0.69
	OGG1	C	105/55
		G	39/25	0.51	0.86	0.47–1.61	0.64
<60	TERT	T	95/91
		C	27/25	0.91	0.94	0.49–1.79	0.86
	CHRNA5	G	89/171
		A	49/71	0.21	1.18	0.73–1.90	0.48
	OGG1	C	103/179
		G	37/63	0.93	1.14	0.68–1.89	0.60

OR = odds ratio; CI = confidence interval; Adj = adjusted. OR and adjusted for smoking and gender. OR adjusted for age and smoking habit. ^aNumbers may not add up total number of patients due to genotype failures. OR adjusted for gender and age. OR adjusted for gender, age and smoking habit.