Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria
Table 5
Association between TERT, CHRNA5, and OGG1 polymorphisms and lung cancer risk, stratified by gender, age, smoking, and histological at the level of alleles.
Population
Gene
Allele
Case/controla
p
ORAdj
CIAdj
Adj
Smokers
TERT
T
132/59
C
50/19
0.60
1.15
0.62–2.18
0.66
CHRNA5
G
128/82
A
80/40
0.30
1.25
0.78–2.03
0.34
OGG1
C
154/93
G
54/29
0.65
1.07
0.64–1.83
0.79
Nonsmokers
TERT
T
55/69
C
11/11
0.62
1.36
0.52–3.54
0.52
CHRNA5
G
52/142
A
22/58
0.91
0.98
0.53–1.78
0.95
OGG1
C
54/141
G
22/59
0.93
0.92
0.50–1.67
0.81
Adenocarcinoma
TERT
T
131/128
C
39/30
0.38
1.16
0.66–2.04
0.57
CHRNA5
G
114/224
A
74/98
0.04
1.33
0.89–1.98
0.15
OGG1
C
137/234
G
53/88
0.88
1.07
0.69–1.63
0.75
Squamous
TERT
T
56/128
C
22/30
0.11
1.48
0.71–3.08
0.28
CHRNA5
G
66/224
A
28/98
0.90
0.87
0.49–1.52
0.64
OGG1
C
71/234
G
23/88
0.58
0.88
0.48–1.60
0.70
Male
TERT
T
146/90
C
52/24
0.30
1.15
0.64–2.11
0.63
CHRNA5
G
145/123
A
87/57
0.21
1.21
0.78–1.87
0.38
OGG1
C
175/133
G
60/47
0.91
0.98
0.61–1.57
0.93
Female
TERT
T
41/38
C
9/6
0.56
1.45
0.47–4.76
0.51
CHRNA5
G
35/101
A
15/41
0.88
0.99
0.47–2.02
0.98
OGG1
C
34/101
G
16/41
0.68
1.07
0.51–2.16
0.85
>60
TERT
T
92/37
C
34/5
0.04
2.21
0.84–6.96
0.13
CHRNA5
G
91/53
A
53/27
0.65
1.12
0.63–2.03
0.69
OGG1
C
105/55
G
39/25
0.51
0.86
0.47–1.61
0.64
<60
TERT
T
95/91
C
27/25
0.91
0.94
0.49–1.79
0.86
CHRNA5
G
89/171
A
49/71
0.21
1.18
0.73–1.90
0.48
OGG1
C
103/179
G
37/63
0.93
1.14
0.68–1.89
0.60
OR = odds ratio; CI = confidence interval; Adj = adjusted. OR and adjusted for smoking and gender. OR adjusted for age and smoking habit. aNumbers may not add up total number of patients due to genotype failures. OR adjusted for gender and age. OR adjusted for gender, age and smoking habit.