The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs

Figure 1

The primary established functions of TIMP2. TIMP2 inhibits several MMPs that cleave a range of substrates that impact structural and cellular aspects of tissue architecture. MMPs, membrane type 1 matrix metalloproteinase (MT1-MMP, also known as MMP-14), and ADAMTS break down ECM and structural proteins during cell invasion, motility, and tumor progression. Through proteolytic functions, TIMP2 affects a vast range of cellular processes in cells and the lung microenvironment. ADAMTS: a disintegrin and metalloproteinase with thrombospondin domains; CCL: CC-chemokine ligand; CXCL: CXC-chemokine ligand; FGF: fibroblast growth factor; FGFR1: FGF receptor 1; IL-1R: interleukin-1 receptor; KITL: KIT ligand; pro-HGF: prohepatocyte growth factor; TGF: transforming growth factor; TNF: tumor necrosis factor; TNFR: TNF receptor; TNFLS11: tumor necrosis factor ligand superfamily member 11; VEGF: vascular endothelial growth factor—created with http://BioRender.com.