Research Article

Characteristics, Management, and Outcomes of Community-Acquired Pneumonia due to Respiratory Syncytial Virus: A Retrospective Study

Table 1

Characteristics of patients admitted with community-acquired pneumonia due to respiratory syncytial virus.

VariableAll patients
ICU admission
No ICU admission
value

Age (years), median (IQR)69.0 (57.5, 79.7)71.0 (57.0, 81.0)66.0 (58.0, 79.0)0.534
Male sex, (%)41 (51.3)13 (68.4)28 (45.9)0.09
BMI (kg/m2), median (IQR)29.0 (24.0, 36.8)31.2 (23.3, 38.5)29.0 (24.0, 36.8)0.874
Smoking, (%)8 (10.0)3 (15.8)5 (8.2)0.335
Comorbidities, (%)
 Diabetes47 (58.8)10 (52.6)37 (60.7)0.535
 Hypertension52 (65.0)12 (63.2)40 (56.6)0.847
 Hypothyroidism13 (16.3)2 (10.5)11 (18.0)0.439
 Heart failure31 (38.8)5 (26.3)26 (42.6)0.203
 Stroke12 (15.0)2 (10.5)10 (16.4)0.532
 Chronic kidney disease19 (23.8)5 (26.3)14 (23.0)0.763
 Dialysis5 (6.3)2 (10.5)3 (4.9)0.378
 Intermittent dialysis21 (26.3)3 (15.8)18 (29.5)0.235
 Dyslipidemia28 (35.0)5 (26.3)23 (37.7)0.363
 Chronic respiratory disease42 (52.5)9 (47.4)33 (54.1)0.608
 Liver disease5 (6.3)1 (5.3)4 (6.6)0.839
 Immunosuppression14 (17.5)4 (21.1)10 (16.4)0.641
 Malignancy4 (5.0)3 (15.8)1 (1.6)0.013
 Transplant8 (10.0)1 (5.3)7 (11.5)0.431
Bedbound, (%)16 (20.0)4 (21.1)12 (19.7)0.895
Presenting symptoms, (%)
 Fever38 (47.5)7 (36.8)31 (50.8)0.287
/min26 (32.5)9 (47.4)17 (27.9)0.113
 mmHg9 (11.3)5 (26.3)4 (6.6)0.017
or >39.9°C12 (15.0)3 (15.8)9 (14.8)0.912
/min17 (21.3)6 (31.6)11 (18.0)0.208
 mmol/L29 (36.3)7 (36.8)22 (36.1)0.951
 Dyspnea71 (88.8)16 (84.2)55 (90.2)0.473
 Dry cough19 (23.8)5 (26.3)14 (23.0)0.763
 Purulent cough58 (72.5)12 (63.2)46 (75.4)0.296
 Chest pain8 (10.0)0 (0.0)8 (13.1)0.096
 Myalgia/arthralgia16 (20.0)4 (21.1)12 (19.7)0.895
 Fatigue21 (26.3)6 (31.6)15 (24.6)0.545
 Headache6 (7.5)3 (15.8)3 (4.9)0.116
 Hemoptysis5 (6.3)1 (5.3)4 (6.6)0.839
Pneumonia severity index, median (IQR)120.5 (94.0, 159.5)140.0 (97.0, 17.1)102.0 (79.0, 145.0)0.085
Laboratory findings, median (IQR)
 White blood cell (109/L)8.9 (5.8, 12.3)7.5 (4.7, 13.5)9.1 (6.3, 12.1)0.619
 Neutrophil (%)70.9 (58.0, 80.5)74.0 (63.4, 86.5)69.6 (50.8, 79.8)0.068
 Lymphocyte (%)14.8 (8.4, 20.7)11.4 (2.8, 19.9)14.9 (9.5, 20.9)0.239
 Hematocrit0.39 (0.34, 0.44)0.38 (0.29, 0.44)0.39 (0.34, 0.44)0.475
 PTT (seconds)29.5 (26.8, 33.9)30.45 (28.3, 33.6)28.5 (26.6, 34.0)0.253
 INR1.16 (1.05, 1.34)1.18 (1.13, 1.27)1.15 (1.04, 1.36)0.571
 Sodium (meq/L)136.0 (133.0, 139.0)136.0 (129.0, 142.0)136 (133, 139)0.793
 Lactic acid (mmol/L)1.86 (1.26, 3.06)2.48 (1.2, 3.0)1.78 (1.26, 2.74)0.405
 Creatinine (μmol/L)86.5 (64.5, 133.75)96.0 (68.0, 163.0)82 (63.5, 129.5)0.553
 pH7.37 (7.30, 7.41)7.37 (7.22, 7.41)7.36 (7.33, 7.41)0.534
 PaO2 (mmHg)63.1 (52.0, 76.0)64.4 (61.4, 81.3)62.9 (48.2, 73.4)0.333
Chest X-ray findings
 Unilateral infiltrates20/74 (27.0)1/19 (5.3)19/55 (34.5)0.015
 Bilateral infiltrates35/74 (47.3)17/19 (89.5)18/55 (32.7)<0.001
 Unilateral pleural effusion13/74 (17.6)3/19 (15.8)10/55 (18.2)1.0
 Bilateral pleural effusion17/74 (23.0)9/19 (47.4)8/55 (14.5)0.009
Chest computed tomography findings
 Unilateral infiltrates8/26 (30.8)1/5 (20.0)7/21 (33.3)1.0
 Bilateral infiltrates7/26 (26.9)2/5 (40.0)5/21 (23.8)0.588
 Unilateral pleural effusion5/26 (19.2)0/5 (0)5/21 (23.8)0.545
 Bilateral pleural effusion7/26 (26.9)2/5 (40.0)5/21 (23.8)0.588

BMI: body mass index; PTT: partial thromboplastin time; INR: international normalized ratio; IQR: interquartile range; MV: mechanical ventilation.