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PPAR Research
Volume 2006, Article ID 71916, 10 pages
Research Article

Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene

1Graduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, Japan
2International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Shinjuku 162-8666, Japan
3Department of Biochemistry, Meiji Pharmaceutical University, Tokyo, Kiyose 204-8588, Japan

Received 16 June 2006; Revised 11 September 2006; Accepted 11 September 2006

Copyright © 2006 Mst. Hasina Akter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many mammalian genes are clustered on the genomes, and hence the genes in the same cluster can be regulated through a common regulatory element. We indeed showed previously that the perilipin/PEX11α gene pair is transactivated tissue-selectively by PPARγ and PPARα, respectively, through a common binding site. In the present study, we identified a gene, named GSPA, neighboring a canonical PPAR target, acyl-CoA oxidase (AOX) gene. GSPA expression was induced by a peroxisome proliferator, Wy14,643, in the liver of wild-type mice, but not PPARα-null mice. GSPA and AOX share the promoter and two peroxisome proliferator-response elements. GSPA mRNA was also found in the heart and skeletal muscle, as well as 3T3-L1 cells. GSPA encodes a protein of 161 amino acids that is enriched in 3T3-L1 cells. Even other gene pairs might be regulated through common sequence elements, and conversely it would be interesting how each gene is aptly regulated in clusters.