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PPAR Research
Volume 2006, Article ID 71916, 10 pages
http://dx.doi.org/10.1155/PPAR/2006/71916
Research Article

Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene

1Graduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, Japan
2International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Shinjuku 162-8666, Japan
3Department of Biochemistry, Meiji Pharmaceutical University, Tokyo, Kiyose 204-8588, Japan

Received 16 June 2006; Revised 11 September 2006; Accepted 11 September 2006

Copyright © 2006 Mst. Hasina Akter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N Adachi and M R Lieber, “Bidirectional gene organization: a common architectural feature of the human genome,” Cell, vol. 109, no. 7, pp. 807–809, 2002. View at Publisher · View at Google Scholar
  2. P Carninci, T Kasukawa, S Katayama et al., “The transcriptional landscape of the mammalian genome,” Science, vol. 309, no. 5740, pp. 1559–1563, 2005. View at Publisher · View at Google Scholar
  3. S Katayama, Y Tomaru, T Kasukawa et al., “Molecular biology: antisense transcription in the mammalian transcriptome,” Science, vol. 309, no. 5740, pp. 1564–1566, 2005. View at Publisher · View at Google Scholar
  4. J M Nickol and G Felsenfeld, “Bidirectional control of the chicken β- and ε-globin genes by a shared enhancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 8, pp. 2548–2552, 1988. View at Publisher · View at Google Scholar
  5. R Godbout, R Ingram, and S M Tilghman, “Multiple regulatory elements in the intergenic region between the α-fetoprotein and albumin genes,” Molecular and Cellular Biology, vol. 6, no. 2, pp. 477–487, 1986. View at Google Scholar
  6. M Shimizu, A Takeshita, T Tsukamoto, F J Gonzalez, and T Osumi, “Tissue-selective, bidirectional regulation of PEX11α and perilipin genes through a common peroxisome proliferator response element,” Molecular and Cellular Biology, vol. 24, no. 3, pp. 1313–1323, 2004. View at Publisher · View at Google Scholar
  7. S A Kliewer, K Umesono, D J Noonan, R A Heyman, and R M Evans, “Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors,” Nature, vol. 358, no. 6389, pp. 771–774, 1992. View at Publisher · View at Google Scholar
  8. M Shimizu, H Akter, Y Emi et al., “Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11a gene pair,” Journal of Biochemistry, vol. 139, no. 3, pp. 563–573, 2006. View at Publisher · View at Google Scholar
  9. K Nagai, T Yamaguchi, T Takami et al., “SKIP modifies gene expression by affecting both transcription and splicing,” Biochemical and Biophysical Research Communications, vol. 316, no. 2, pp. 512–517, 2004. View at Publisher · View at Google Scholar
  10. S Osada, T Tsukamoto, M Takiguchi, M Mori, and T Osumi, “Identification of an extended half-site motif required for the function of peroxisome proliferator-activated receptor α,” Genes to Cells, vol. 2, no. 5, pp. 315–327, 1997. View at Publisher · View at Google Scholar
  11. T Osumi, J.-K Wen, and T Hashimoto, “Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene,” Biochemical and Biophysical Research Communications, vol. 175, no. 3, pp. 866–871, 1991. View at Publisher · View at Google Scholar
  12. J Sambrook and D W Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Woodbury, NY, 2001.
  13. T Yamaguchi, S Matsushita, K Motojima, F Hirose, and T Osumi, “MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptorα,” Journal of Biological Chemistry, vol. 281, no. 20, pp. 14232–14240, 2006. View at Publisher · View at Google Scholar
  14. T Osumi, N Ishii, S Miyazawa, and T Hashimoto, “Isolation and structural characterization of the rat acyl-CoA oxidase gene,” Journal of Biological Chemistry, vol. 262, no. 17, pp. 8138–8143, 1987. View at Google Scholar
  15. J D Tugwood, I Issemann, R G Anderson, K R Bundell, W L McPheat, and S Green, “The mouse peroxisome proliferator activated receptor recognizes a response element in the 5 flanking sequence of the rat acyl CoA oxidase gene,” EMBO Journal, vol. 11, no. 2, pp. 433–439, 1992. View at Google Scholar
  16. S S-T Lee, T Pineau, J Drago et al., “Targeted disruption of the a isoform of the peroxisome proliferator- activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators,” Molecular and Cellular Biology, vol. 15, no. 6, pp. 3012–3022, 1995. View at Google Scholar
  17. T Shimada, H Fujii, and H Lin, “A 165-base pair sequence between the dihydrofolate reductase gene and the divergently transcribed upstream gene is sufficient for bidirectional transcriptional activity,” Journal of Biological Chemistry, vol. 264, no. 34, pp. 20171–20174, 1989. View at Google Scholar
  18. P J Mitchell, A M Carothers, J H Han et al., “Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene,” Molecular and Cellular Biology, vol. 6, no. 2, pp. 425–440, 1986. View at Google Scholar
  19. J Patton, S Block, C Coombs, and M E Martin, “Identification of functional elements in the murine Gabpα/ATP synthase coupling factor 6 bi-directional promoter,” Gene, vol. 369, no. 1-2, pp. 35–44, 2006. View at Publisher · View at Google Scholar
  20. A G West and P Fraser, “Remote control of gene transcription,” Human Molecular Genetics, vol. 14, no. 1, pp. R101–R111, 2005. View at Publisher · View at Google Scholar
  21. M.-H Hsu, Ü Savas, K J Griffin, and E F Johnson, “Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor α in HepG2 cells,” Journal of Biological Chemistry, vol. 276, no. 30, pp. 27950–27958, 2001. View at Publisher · View at Google Scholar
  22. U Varanasi, R Chu, Q Huang, R Castellon, A V Yeldandi, and J K Reddy, “Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene,” Journal of Biological Chemistry, vol. 271, no. 4, pp. 2147–2155, 1996. View at Publisher · View at Google Scholar