Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2007, Article ID 26839, 13 pages
http://dx.doi.org/10.1155/2007/26839
Research Article

Comprehensive Analysis of PPARα-Dependent Regulation of Hepatic Lipid Metabolism by Expression Profiling

1Nutrigenomics Consortium, Wageningen Centre for Food Sciences, P.O. BOX 557, Wageningen 6700 AN, The Netherlands
2Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, P.O. BOX 8129, Wageningen 6700 EV, The Netherlands
3Life Sciences Research Unit, University of Luxembourg, 162A Avenue de la Faïencerie, Luxembourg 1511, Luxembourg

Received 17 May 2007; Accepted 25 July 2007

Academic Editor: Michael L. Cunningham

Copyright © 2007 Maryam Rakhshandehroo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [135 citations]

The following is the list of published articles that have cited the current article.

  • Merja Heinäniemi, J. Oskari Uski, Tatjana Degenhardt, and Carsten Carlberg, “Meta-analysis of primary target genes of peroxisome proliferator-activated receptors,” Genome Biology, vol. 8, no. 7, 2007. View at Publisher · View at Google Scholar
  • Mauricio Berriel Diaz, Anja Krones-Herzig, Dagmar Metzger, Anja Ziegler, Alexandros Vegiopoulos, Martin Klingenspor, Karin Müller-Decker, and Stephan Herzig, “Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice,” Hepatology, vol. 48, no. 3, pp. 782–791, 2008. View at Publisher · View at Google Scholar
  • Mitchell B. Rosen, Barbara D. Abbott, Douglas C. Wolf, J. Christopher Corton, Carmen R. Wood, Judith E. Schmid, Kaberi P. Das, Robert D. Zehr, Eric T. Blair, and Christopher Lau, “Gene Profiling in the Livers of Wild-type and PPAR alpha-Null Mice Exposed to Perfluorooctanoic Acid,” Toxicologic Pathology, vol. 36, no. 4, pp. 592–607, 2008. View at Publisher · View at Google Scholar
  • Colette Desert, Michel J. Duclos, Pierre Blavy, Frederic Lecerf, Francois Moreews, Christophe Klopp, Marc Aubry, Frederic Herault, Pascale Le Roy, Cecile Berri, Madeleine Douaire, Christian Diot, and Sandrine Lagarrigue, “Transcriptome profiling of the feeding-to-fasting transition in chicken liver,” Bmc Genomics, vol. 9, 2008. View at Publisher · View at Google Scholar
  • Hannelore Daniel, Christian A. Drevon, Ulla I. Klein, Robert Kleemann, and Ben van Ommen, “The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level,” Genes And Nutrition, vol. 3, no. 3-4, pp. 101–106, 2008. View at Publisher · View at Google Scholar
  • Mary C. Hunt, and Stefan E.H. Alexson, “Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism,” Progress in Lipid Research, vol. 47, no. 6, pp. 405–421, 2008. View at Publisher · View at Google Scholar
  • Katsutaka Oishi, Daisuke Uchida, and Norio Ishida, “Circadian expression of FGF21 is induced by PPARα activation in the mouse liver,” FEBS Letters, vol. 582, no. 25-26, pp. 3639–3642, 2008. View at Publisher · View at Google Scholar
  • Jun Yan, Haifang Wang, Yuting Liu, and Chunxuan Shao, “Analysis of gene regulatory networks in the mammalian circadian rhythm,” PLoS Computational Biology, vol. 4, no. 10, 2008. View at Publisher · View at Google Scholar
  • Rinke Stienstra, Fredy Saudale, Caroline Duval, Shohreh Keshtkar, Johanna E. M. Groener, Nico van Rooijen, Bart Staels, Sander Kersten, and Michael Müller, “Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity,” Hepatology, vol. 51, no. 2, pp. 511–522, 2009. View at Publisher · View at Google Scholar
  • Maryam Rakhshandehroo, Guido Hooiveld, Michael Muller, and Sander Kersten, “Comparative Analysis of Gene Regulation by the Transcription Factor PPAR alpha between Mouse and Human,” Plos One, vol. 4, no. 8, 2009. View at Publisher · View at Google Scholar
  • Sander Kersten, and Michael Müller, “Dropping liver fat droplets,” Hepatology, vol. 50, no. 2, pp. 645–647, 2009. View at Publisher · View at Google Scholar
  • Jie Wei, Hye Won Kang, and David E. Cohen, “Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): A homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs,” Biochemical Journal, vol. 421, no. 2, pp. 311–322, 2009. View at Publisher · View at Google Scholar
  • N. J. Hickey, D. Crump, S. P. Jones, and S. W. Kennedy, “Effects of 18 Perfluoroalkyl Compounds on mRNA Expression in Chicken Embryo Hepatocyte Cultures,” Toxicological Sciences, vol. 111, no. 2, pp. 311–320, 2009. View at Publisher · View at Google Scholar
  • Tatjana Degenhardt, Sami Vaisanen, Maryam Rakhshandehroo, Sander Kersten, and Carsten Carlberg, “Peroxisome Proliferator-Activated Receptor a controls Hepatic Heme Biosynthesis Through ALAS1,” Journal Of Molecular Biology, vol. 388, no. 2, pp. 225–238, 2009. View at Publisher · View at Google Scholar
  • Aparna Purushotham, Thaddeus T. Schug, Qing Xu, Sailesh Surapureddi, Xiumei Guo, and Xiaoling Li, “Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation,” Cell Metabolism, vol. 9, no. 4, pp. 327–338, 2009. View at Publisher · View at Google Scholar
  • Johan Fernø, Audun O. Vik-Mo, Goran Jassim, Bjarte Håvik, Kjetil Berge, Silje Skrede, Oddrun A. Gudbrandsen, Jo Waage, Niclas Lunder, Sverre Mørk, Rolf K. Berge, Hugo A. Jørgensen, and Vidar M. Steen, “Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver,” Psychopharmacology, vol. 203, no. 1, pp. 73–84, 2009. View at Publisher · View at Google Scholar
  • Fa-Xing Yu, and Yan Luo, “Tandem ChoRE and CCAAT Motifs and Associated Factors Regulate Txnip Expression in Response to Glucose or Adenosine-Containing Molecules,” Plos One, vol. 4, no. 12, 2009. View at Publisher · View at Google Scholar
  • Duccio Cavalieri, Enrica Calura, Chiara Romualdi, Emmanuela Marchi, Marijana Radonjic, Ben Van Ommen, and Michael Muller, “Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis,” Bmc Genomics, vol. 10, 2009. View at Publisher · View at Google Scholar
  • Linda M. Sanderson, Tatjana Degenhardt, Arjen Koppen, Eric Kalkhoven, Beatrice Desvergne, Michael Mülle, and Sander Kersten, “Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) but not PPARα serves as a plasma free fatty acid sensor in liver,” Molecular and Cellular Biology, vol. 29, no. 23, pp. 6257–6267, 2009. View at Publisher · View at Google Scholar
  • Anke Gutgesell, Gaiping Wen, Bettina König, Alexander Koch, Julia Spielmann, Gabriele I. Stangl, Klaus Eder, and Robert Ringseis, “Mouse carnitine–acylcarnitine translocase (CACT) is transcriptionally regulated by PPARα and PPARδ in liver cells,” Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1790, no. 10, pp. 1206–1216, 2009. View at Publisher · View at Google Scholar
  • Q. T. Tran, L. Xu, V. Phan, S. B. Goodwin, M. Rahman, V. X. Jin, C. H. Sutter, B. D. Roebuck, T. W. Kensler, E.O. George, and T. R. Sutter, “Chemical genomics of cancer chemopreventive dithiolethiones,” Carcinogenesis, vol. 30, no. 3, pp. 480–486, 2009. View at Publisher · View at Google Scholar
  • Donald J. Abraham, Peter T.W. Cheng, Ellen Kick, and Ranjan MukherjeeBurger's Medicinal Chemistry and Drug Discovery, 2010. View at Publisher · View at Google Scholar
  • Wenqing Zhao, Olivia Fong, Eric S. Muise, John R. Thompson, Drew Weingarth, Su Qian, and Tung M. Fong, “Genome-wide Expression Profiling Revealed Peripheral Effects of Cannabinoid Receptor 1 Inverse Agonists in Improving Insulin Sensitivity and Metabolic Parameters,” Molecular Pharmacology, vol. 78, no. 3, pp. 350–359, 2010. View at Publisher · View at Google Scholar
  • Hye Won Kang, Jie Wei, and David E. Cohen, “PC-TP/StARD2: Of membranes and metabolism,” Trends in Endocrinology and Metabolism, vol. 21, no. 7, pp. 449–456, 2010. View at Publisher · View at Google Scholar
  • Anastasia Georgiadi, Laeticia Lichtenstein, Tatjana Degenhardt, Mark V. Boekschoten, Marc van Bilsen, Beatrice Desvergne, Michael Muller, and Sander Kersten, “Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor beta/delta and Protects Against Fatty Acid-Induced Oxidative Stress,” Circulation Research, vol. 106, no. 11, pp. 1712–1721, 2010. View at Publisher · View at Google Scholar
  • Carsten Carlberg, and Merja Heinäniemi, “ The Impact of Whole Genome In Silico Screening for Nuclear Receptor-Binding Sites in Systems Biology ,” Elements of Computational Systems Biology, pp. 309–324, 2010. View at Publisher · View at Google Scholar
  • Hye Won Kang, Keishi Kanno, Erez F. Scapa, and David E. Cohen, “Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPAR alpha),” Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids, vol. 1801, no. 4, pp. 496–502, 2010. View at Publisher · View at Google Scholar
  • Gustavo J. Hein, Ana M. Bernasconi, Mauro A. Montanaro, Magali Pellon-Maison, Gabriela Finarelli, Adriana Chicco, Yolanda B. Lombardo, and Rodolfo R. Brenner, “Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids,” American Journal of Physiology - Endocrinology and Metabolism, vol. 298, no. 3, pp. E429–E439, 2010. View at Publisher · View at Google Scholar
  • Ming-Yue Li, Huiling Yuan, Lily T. Ma, Angel W. Y. Kong, Michael K. Y. Hsin, Johnson H. Y. Yip, Malcolm J. Underwood, and George G. Chen, “Roles of Peroxisome Proliferator-Activated Receptor-alpha and -gamma in the Development of Non-Small Cell Lung Cancer,” American Journal Of Respiratory Cell And Molecular Biology, vol. 43, no. 6, pp. 674–683, 2010. View at Publisher · View at Google Scholar
  • Benjamin R. Carone, Lucas Fauquier, Naomi Habib, Jeremy M. Shea, Caroline E. Hart, Ruowang Li, Christoph Bock, Chengjian Li, Hongcang Gu, Phillip D. Zamore, Alexander Meissner, Zhiping Weng, Hans A. Hofmann, Nir Friedman, and Oliver J. Rando, “Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals,” Cell, vol. 143, no. 7, pp. 1084–1096, 2010. View at Publisher · View at Google Scholar
  • D. L. M. van der Meer, T. Degenhardt, S. Vaisanen, P. J. de Groot, M. Heinaniemi, S. C. de Vries, M. Muller, C. Carlberg, and S. Kersten, “Profiling of promoter occupancy by PPAR  in human hepatoma cells via ChIP-chip analysis,” Nucleic Acids Research, vol. 38, no. 9, pp. 2839–2850, 2010. View at Publisher · View at Google Scholar
  • Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, and Sander Kersten, “Peroxisome Proliferator-Activated Receptor Alpha Target Genes,” PPAR Research, vol. 2010, pp. 1–20, 2010. View at Publisher · View at Google Scholar
  • Labar, Wouters, and Lambert, “A review on the monoacylglycerol lipase: At the interface between fat and endocannabinoid signalling,” Current Medicinal Chemistry, vol. 17, no. 24, pp. 2588–2607, 2010. View at Publisher · View at Google Scholar
  • Maisa Silva, Larissa de Freitas Bonomo, Riva de Paula Oliveira, Wanderson Geraldo de Lima, Marcelo Eustaquio Silva, and Maria Lucia Pedrosa, “Effects of the interaction of diabetes and iron supplementation on hepatic and pancreatic tissues, oxidative stress markers, and liver peroxisome proliferator-activated receptor-alpha expression,” Journal Of Clinical Biochemistry And Nutrition, vol. 49, no. 2, pp. 102–108, 2011. View at Publisher · View at Google Scholar
  • Kristopher W. Krausz, Jeffrey R. Idle, Albert J. Fornace, Frank J. Gonzalez, Soumen K. Manna, Andrew D. Patterson, and Qian Yang, “ UPLC–MS-based Urine Metabolomics Reveals Indole-3-lactic Acid and Phenyllactic Acid as Conserved Biomarkers for Alcohol-induced Liver Disease in the Ppara -null Mouse Model ,” Journal of Proteome Research, vol. 10, no. 9, pp. 4120–4133, 2011. View at Publisher · View at Google Scholar
  • A. Kuhla, T. Blei, R. Jaster, and B. Vollmar, “Aging Is Associated With a Shift of Fatty Metabolism Toward Lipogenesis,” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 66A, no. 11, pp. 1192–1200, 2011. View at Publisher · View at Google Scholar
  • Nora Martinez, Melisa Kurtz, Evangelina Capobianco, Romina Higa, Veronica White, and Alicia Jawerbaum, “PPAR alpha agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats,” Journal Of Molecular Endocrinology, vol. 47, no. 1, pp. 1–12, 2011. View at Publisher · View at Google Scholar
  • Marco Fidaleo, Ségolène Arnauld, Marie-Claude Clémencet, Grégory Chevillard, Marie-Charlotte Royer, Melina De Bruycker, Ronald J.A. Wanders, Anne Athias, Joseph Gresti, Pierre Clouet, Pascal Degrace, Sander Kersten, Marc Espeel, Norbert Latruffe, Valérie Nicolas-Francès, and Stéphane Mandard, “A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver,” Biochimie, vol. 93, no. 5, pp. 876–891, 2011. View at Publisher · View at Google Scholar
  • Michelle L. Mujoomdar, Laura M. Hogan, Albert F. Parlow, and Mark W. Nachtigal, “Pcsk6 mutant mice exhibit progressive loss of ovarian function, altered gene expression, and formation of ovarian pathology,” Reproduction, vol. 141, no. 3, pp. 343–355, 2011. View at Publisher · View at Google Scholar
  • N. C. Roy, E. Altermann, Z. A. Park, and W. C. McNabb, “A comparison of analog and Next-Generation transcriptomic tools for mammalian studies,” Briefings in Functional Genomics, vol. 10, no. 3, pp. 135–150, 2011. View at Publisher · View at Google Scholar
  • Raymond Bidlack, Wayne Rodriguez, and Sander Kersten, “Nutrigenomics of Fatty Acid Sensing,” Nutritional Genomics, pp. 173–184, 2011. View at Publisher · View at Google Scholar
  • Augustine Arukwe, and Anne S. Mortensen, “Lipid peroxidation and oxidative stress responses of salmon fed a diet containing perfluorooctane sulfonic- or perfluorooctane carboxylic acids,” Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol. 154, no. 4, pp. 288–295, 2011. View at Publisher · View at Google Scholar
  • Shinichi Oka, Ralph Alcendor, Peiyong Zhai, Ji Yeon Park, Dan Shao, Jaeyeaon Cho, Takanobu Yamamoto, Bin Tian, and Junichi Sadoshima, “PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway,” Cell Metabolism, vol. 14, no. 5, pp. 598–611, 2011. View at Publisher · View at Google Scholar
  • Peng Cheng, Sheng Sheng Yang, Xian Gui Hu, Xu Yu Zhou, Yi Jie Zhang, Gang Jin, and Ying Qi Zhou, “Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha,” FEBS Letters, vol. 585, no. 21, pp. 3403–3408, 2011. View at Publisher · View at Google Scholar
  • Nora Martinez, Veronica White, Melisa Kurtz, Romina Higa, Evangelina Capobianco, and Alicia Jawerbaum, “Activation of the nuclear receptor PPAR alpha regulates lipid metabolism in foetal liver from diabetic rats: implications in diabetes-induced foetal overgrowth,” Diabetes-Metabolism Research And Reviews, vol. 27, no. 1, pp. 35–46, 2011. View at Publisher · View at Google Scholar
  • Najoua Guelzim, Jean-François Huneau, Véronique Mathé, Annie Quignard-Boulangé, Pascal G. Martin, Daniel Tomé, and Dominique Hermier, “Consequences of PPARα Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids,” PPAR Research, vol. 2011, pp. 1–10, 2011. View at Publisher · View at Google Scholar
  • Kan He, Qishan Wang, Yumei Yang, Minghui Wang, and Yuchun Pan, “A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis,” PPAR Research, vol. 2011, pp. 1–10, 2011. View at Publisher · View at Google Scholar
  • Arkaitz Carracedo, Dror Weiss, Amy K. Leliaert, Manoj Bhasin, Vincent C.J. de Boer, Gaelle Laurent, Andrew C. Adams, Maria Sundvall, Su Jung Song, Keisuke Ito, Lydia S. Finley, Ainara Egia, Towia Libermann, Zachary Gerhart-Hines, Pere Puigserver, Marcia C. Haigis, Elefteria Maratos-Flier, Andrea L. Richardson, Zachary T. Schafer, and Pier P. Pandolfi, “A metabolic prosurvival role for PML in breast cancer,” Journal of Clinical Investigation, vol. 122, no. 9, pp. 3088–3100, 2012. View at Publisher · View at Google Scholar
  • Fei Li, Andrew D. Patterson, Kristopher W. Krausz, Naoki Tanaka, and Frank J. Gonzalez, “Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis,” Journal Of Lipid Research, vol. 53, no. 8, pp. 1625–1635, 2012. View at Publisher · View at Google Scholar
  • Emilio P. Mottillo, Ainsley E. Bloch, Todd Leff, and James G. Granneman, “Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) alpha and delta in Brown Adipocytes to Match Fatty Acid Oxidation with Supply,” Journal Of Biological Chemistry, vol. 287, no. 30, pp. 25038–25048, 2012. View at Publisher · View at Google Scholar
  • Werner J. Kovacs, Khanichi N. Charles, Katharina M. Walter, Janis E. Shackelford, Thomas M. Wikander, Michael J. Richards, Steven J. Fliesler, Skaidrite K. Krisans, and Phyllis L. Faust, “Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1821, no. 6, pp. 895–907, 2012. View at Publisher · View at Google Scholar
  • Esther M.E. van Straten, Vincent W. Bloks, Theo H. van Dijk, Julius F.W. Baller, Nicolette C.A. Huijkman, Irma Kuipers, Henkjan J. Verkade, and Torsten Plösch, “Sex-Dependent Programming of Glucose and Fatty Acid Metabolism in Mouse Offspring by Maternal Protein Restriction,” Gender Medicine, vol. 9, no. 3, pp. 166–179.e13, 2012. View at Publisher · View at Google Scholar
  • Mohammad Ohid Ullah, Michael Müller, and Guido J.E.J. Hooiveld, “An integrated statistical approach to compare transcriptomics data across experiments: A case study on the identification of candidate target genes of the transcription factor PPARα,” Bioinformatics and Biology Insights, vol. 6, pp. 145–154, 2012. View at Publisher · View at Google Scholar
  • Maryam Rakhshandehroo, Rinke Stienstra, Nicole J. de Wit, Marjolijn C. E. Bragt, Martin Haluzik, Ronald P. Mensink, Michael Mueller, and Sander Kersten, “Plasma mannose-binding lectin is stimulated by PPAR alpha in humans,” American Journal of Physiology-Endocrinology and Metabolism, vol. 302, no. 5, pp. E595–E602, 2012. View at Publisher · View at Google Scholar
  • Ping-Hsiao Shih, Sam-Long Hwang, Chi-Tai Yeh, and Gow-Chin Yen, “Synergistic Effect of Cyanidin and PPAR Agonist against Nonalcoholic Steatohepatitis-Mediated Oxidative Stress-Induced Cytotoxicity through MAPK and Nrf2 Transduction Pathways,” Journal of Agricultural and Food Chemistry, vol. 60, no. 11, pp. 2924–2933, 2012. View at Publisher · View at Google Scholar
  • Nicole Wege, Alexandra Schutkowski, Bettina König, Corinna Brandsch, Matthias Weiwad, and Gabriele I. Stangl, “PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model,” Molecular Nutrition & Food Research, vol. 57, no. 3, pp. 376–389, 2012. View at Publisher · View at Google Scholar
  • Snezana Mirkov, Jamie L. Myers, Jacqueline Ramírez, and Wanqing Liu, “SNPs affecting serum metabolomic traits may regulate gene transcription and lipid accumulation in the liver,” Metabolism, vol. 61, no. 11, pp. 1523–1527, 2012. View at Publisher · View at Google Scholar
  • Tarek Moustafa, Peter Fickert, Christoph Magnes, Christian Guelly, Andrea Thueringer, Sasa Frank, Dagmar Kratky, Wolfgang Sattler, Helga Reicher, Frank Sinner, Judith Gumhold, Dagmar Silbert, Günter Fauler, Gerald Höfler, Achim Lass, Rudolf Zechner, and Michael Trauner, “Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury,” Gastroenterology, vol. 142, no. 1, pp. 140–151.e12, 2012. View at Publisher · View at Google Scholar
  • Robert F. Schwabe, and Jacquelyn J. Maher, “Lipids in Liver Disease: Looking Beyond Steatosis,” Gastroenterology, vol. 142, no. 1, pp. 8–11, 2012. View at Publisher · View at Google Scholar
  • Kristian K. Jensen, Stephen F. Previs, Lei Zhu, Kithsiri Herath, Sheng-Ping Wang, Gowri Bhat, Guanghui Hu, Paul L. Miller, David G. McLaren, Myung K. Shin, Thomas F. Vogt, Liangsu Wang, Kenny K. Wong, Thomas P. Roddy, Douglas G. Johns, and Brian K. Hubbard, “Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and (H2O)-H-2 quantification,” American Journal Of Physiology-Endocrinology And Metabolism, vol. 302, no. 2, pp. E209–E217, 2012. View at Publisher · View at Google Scholar
  • Shi Nan Yin, Min Liu, Dan Qing Jing, Yi Ming Mu, Ju Ming Lu, and Chang Yu Pan, “Telmisartan increases lipoprotein lipase expression via peroxisome proliferator-activated receptor-alpha in HepG2 cells,” Endocrine Research, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Yichi Xu, Chunxuan Shao, Vadim B. Fedorov, Anna V. Goropashnaya, Brian M. Barnes, and Jun Yan, “Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes,” Bmc Genomics, vol. 14, 2013. View at Publisher · View at Google Scholar
  • Anne S. Kienhuis, Alexa P. Vitins, Jeroen L.A. Pennings, Tessa E. Pronk, Ewoud N. Speksnijder, Marianne Roodbergen, Joost H.M. van Delft, Mirjam Luijten, and Leo T.M. van der Ven, “Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis,” Toxicology Letters, 2013. View at Publisher · View at Google Scholar
  • Aaron L. Sverdlov, Wai P.A. Chan, Nathan E.K. Procter, Yuliy Y. Chirkov, Doan T.M. Ngo, and John D. Horowitz, “Reciprocal regulation of NO signaling and TXNIP expression in humans: impact of aging and ramipril therapy,” International Journal of Cardiology, 2013. View at Publisher · View at Google Scholar
  • Kan He, Qishan Wang, Zhen Wang, and Yuchun Pan, “Association study between gene polymorphisms in PPAR signaling pathway and porcine meat quality traits,” Mammalian Genome, 2013. View at Publisher · View at Google Scholar
  • Kathrin A. Zierler, Doris Jaeger, Nina M. Pollak, Sandra Eder, Gerald N. Rechberger, Franz P. W. Radner, Gerald Woelkart, Dagmar Kolb, Albrecht Schmidt, Manju Kumari, Karina Preiss-Landl, Burkert Pieske, Bernd Mayer, Robert Zimmermann, Achim Lass, Rudolf Zechner, and Guenter Haemmerle, “Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58,” Journal Of Biological Chemistry, vol. 288, no. 14, pp. 9892–9904, 2013. View at Publisher · View at Google Scholar
  • Xiaopo Zhang, Chongming Wu, Haifeng Wu, Linghui Sheng, Yan Su, Xue Zhang, Hong Luan, Guibo Sun, Xiaobo Sun, Yu Tian, Yubin Ji, Peng Guo, and Xudong Xu, “Anti-Hyperlipidemic Effects and Potential Mechanisms of Action of the Caffeoylquinic Acid-Rich Pandanus tectorius Fruit Extract in Hamsters Fed a High Fat-Diet,” Plos One, vol. 8, no. 4, 2013. View at Publisher · View at Google Scholar
  • Peter A. Crawford, and Jean E. Schaffer, “Metabolic stress in the myocardium: Adaptations of gene expression,” Journal of Molecular and Cellular Cardiology, vol. 55, pp. 130–138, 2013. View at Publisher · View at Google Scholar
  • Jihan A. Youssef, and Mostafa Z. Badrpp. 1–137, 2013. View at Publisher · View at Google Scholar
  • Patrick D. McMullen, Sudin Bhattacharya, Courtney G. Woods, Bin Sun, Kathy Yarborough, Susan M. Ross, Manda E. Miller, Mary McBride, Edward L. LeCluyse, Rebecca A. Clewell, and Melvin E. Andersen, “A map of the PPARα transcription regulatory network for primary human hepatocytes,” Chemico-Biological Interactions, 2013. View at Publisher · View at Google Scholar
  • Gaelle Laurent, Vincent C. J. de Boer, Lydia W. S. Finley, Meredith Sweeney, Hong Lu, Thaddeus T. Schug, Yana Cen, Seung Min Jeong, Xiaoling Li, Anthony A. Sauve, and Marcia C. Haigis, “SIRT4 Represses Peroxisome Proliferator-Activated Receptor alpha Activity To Suppress Hepatic Fat Oxidation,” Molecular and Cellular Biology, vol. 33, no. 22, pp. 4552–4561, 2013. View at Publisher · View at Google Scholar
  • Fredrik F. Venold, Michael H. Penn, Jim Thorsen, Jinni Gu, Trond M. Kortner, Ashild Krogdahl, and Anne Marie Bakke, “Intestinal fatty acid binding protein (fabp2) in Atlantic salmon (Salmo salar): Localization and alteration of expression during development of diet induced enteritis,” Comparative Biochemistry And Physiology A-Molecular & Integrative Physiolog, vol. 164, no. 1, pp. 229–240, 2013. View at Publisher · View at Google Scholar
  • Yuchun Pan, Kan He, Zhen Wang, and Qishan Wang, “A meta-analysis study of gene expression datasets in mouse liver under PPAR alpha knockout,” Genetics Research, vol. 95, no. 2-3, pp. 78–88, 2013. View at Publisher · View at Google Scholar
  • Minako Karahashi, Miki Hoshina, Tohru Yamazaki, Takeshi Sakamoto, Atsushi Mitsumoto, Yoichi Kawashima, and Naomi Kudo, “Fibrates Reduce Triacylglycerol Content by Upregulating Adipose Triglyceride Lipase in the Liver of Rats,” Journal of Pharmacological Sciences, 2013. View at Publisher · View at Google Scholar
  • David G. Cotter, Baris Ercal, D. Andre d'Avignon, Dennis J. Dietzen, and Peter A. Crawford, “Impairments of hepatic gluconeogenesis and ketogenesis in PPAR alpha-deficient neonatal mice,” American Journal of Physiology-Endocrinology and Metabolism, vol. 307, no. 2, pp. E176–E185, 2014. View at Publisher · View at Google Scholar
  • Sayaka Inokuchi-Shimizu, Eek Joong Park, Yoon Seok Roh, Ling Yang, Bi Zhang, Jingyi Song, Shuang Liang, Michael Pimienta, Koji Taniguchi, Xuefeng Wu, Kinji Asahina, William Lagakos, Mason R. Mackey, Shizuo Akira, Mark H. Ellisman, Dorothy D. Sears, Jerrold M. Olefsky, Michael Karin, David A. Brenner, and Ekihiro Seki, “TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis,” Journal of Clinical Investigation, 2014. View at Publisher · View at Google Scholar
  • Menghan Liu, Magdalene K. Montgomery, Corrine E. Fiveash, Brenna Osborne, Gregory J. Cooney, Kim Bell-Anderson, and Nigel Turner, “PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis,” Scientific Reports, vol. 4, 2014. View at Publisher · View at Google Scholar
  • Frits Mattijssen, Anastasia Georgiadi, Tresty Andasarie, Ewa Szalowska, Annika Zota, Anja Krones-Herzig, Christoph Heier, Dariusz Ratman, Karolien De Bosscher, Ling Qi, Rudolf Zechner, Stephan Herzig, and Sander Kersten, “Hypoxia-inducible Lipid Droplet-associated (HILPDA) Is a Novel Peroxisome Proliferator-activated Receptor (PPAR) Target Involved in Hepatic Triglyceride Secretion,” Journal of Biological Chemistry, vol. 289, no. 28, pp. 19279–19293, 2014. View at Publisher · View at Google Scholar
  • Marcin Buler, Sanna-Mari Aatsinki, Valerio Izzi, Johanna Uusimaa, and Jukka Hakkola, “SIRT5 is under the control of PGC-1 alpha and AMPK and is involved in regulation of mitochondrial energy metabolism,” Faseb Journal, vol. 28, no. 7, pp. 3225–3237, 2014. View at Publisher · View at Google Scholar
  • Michael S. Lustgarten, Lori L. Price, Angela Chalé, and Roger A. Fielding, “Metabolites related to gut bacterial metabolism, peroxisome proliferator-activated receptor-alpha activation, and insulin sensitivity are associated with physical function in functionally-limited older adults,” Aging Cell, 2014. View at Publisher · View at Google Scholar
  • Klemens Kienesberger, Aniko Ginta Pordes, Thomas Georg Voelk, and Reinhold Hofbauer, “L-carnitine and PPAR alpha-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cells,” Bmc Genomics, vol. 15, 2014. View at Publisher · View at Google Scholar
  • Guang-feng Ming, Xi Li, Ji-ye Yin, Yu-hang Ai, Dao-miao Xu, Xin-hua Ma, Zhi-yong Liu, Hui-xia Liu, Hong-hao Zhou, and Zhao-qian Liu, “JAZF1 regulates visfatin expression in adipocytes via PPARα and PPARβ/δ signaling,” Metabolism, 2014. View at Publisher · View at Google Scholar
  • Janna A. van Diepen, Patrick A. Jansen, Dov B. Ballak, Anneke Hijmans, Guido J. Hooiveld, Samuel Rommelaere, Franck Galland, Philippe Naquet, Floris P.J.T. Rutjes, Ronald P. Mensink, Patrick Schrauwen, Cees J. Tack, Mihai G. Netea, Sander Kersten, Joost Schalkwijk, and Rinke Stienstra, “PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism,” Journal of Hepatology, 2014. View at Publisher · View at Google Scholar
  • M. Jawad Khan, Carolina B. Jacometo, Daniel E. Graugnard, Marcio N. Corrêa, Eduardo Schmitt, Felipe Cardoso, and Juan J. Loor, “Overfeeding dairy cattle during late-pregnancy alters hepatic pparα-regulated pathways including hepatokines: Impact on metabolism and peripheral insulin sensitivity,” Gene Regulation and Systems Biology, vol. 2014, no. 8, pp. 97–111, 2014. View at Publisher · View at Google Scholar
  • Sander Kersten, “Integrated physiology and systems biology of PPARα,” Molecular Metabolism, 2014. View at Publisher · View at Google Scholar
  • Ewa Szalowska, Haftu A. Tesfay, Sacha A. F. T. van Hijum, and Sander Kersten, “Transcriptomic signatures of peroxisome proliferator-activated receptor alpha (PPAR alpha) in different mouse liver models identify novel aspects of i,” Bmc Genomics, vol. 15, 2014. View at Publisher · View at Google Scholar
  • Yuan-Fu Lu, Yun-Yan Xu, Feng Jin, Qin Wu, Jing-Shan Shi, and Jie Liu, “Icariin Is A PPAR alpha Activator Inducing Lipid Metabolic Gene Expression in Mice,” Molecules, vol. 19, no. 11, pp. 18179–18191, 2014. View at Publisher · View at Google Scholar
  • Michal Pawlak, Philippe Lefebvre, and Bart Staels, “Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease,” Journal of Hepatology, 2014. View at Publisher · View at Google Scholar
  • Jie Chang, Shinji Oikawa, Hitoshi Iwahashi, Emiko Kitagawa, Ichiro Takeuchi, Masao Yuda, Chieko Aoki, Yoshiji Yamada, Gaku Ichihara, Masashi Kato, and Sahoko Ichihara, “Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat,” Diabetology & Metabolic Syndrome, vol. 6, 2014. View at Publisher · View at Google Scholar
  • Martinez-Arguelles, Campioli, Lienhart, Fan, Culty, Zirkin, and Papadopoulos, “In utero exposure to the endocrine disruptor di-(2- ethylhexyl) phthalate induces long-term changes in gene expression in the adult male adrenal gland,” Endocrinology, vol. 155, no. 5, pp. 1667–1678, 2014. View at Publisher · View at Google Scholar
  • Karolin Weitkunat, Sara Schumann, Klaus Juergen Petzke, Michael Blaut, Gunnar Loh, and Susanne Klaus, “Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice,” Journal Of Nutritional Biochemistry, vol. 26, no. 9, pp. 929–937, 2015. View at Publisher · View at Google Scholar
  • Michael S. Lustgarten, Lori Lyn Price, and Roger A. Fielding, “Analytes and Metabolites Associated with Muscle Quality in Young, Healthy Adults,” Medicine & Science in Sports & Exercise, vol. 47, no. 8, pp. 1659–1664, 2015. View at Publisher · View at Google Scholar
  • John Tzeng, Jaemin Byun, Ji Yeon Park, Takanobu Yamamoto, Kevin Schesing, Bin Tian, Junichi Sadoshima, and Shin-ichi Oka, “An Ideal PPAR Response Element Bound to and Activated by PPAR alpha,” Plos One, vol. 10, no. 8, 2015. View at Publisher · View at Google Scholar
  • Yun Zhao, Lu Peng, Li-chao Yang, Xu-dong Xu, Wei-jie Li, Xiu-mei Luo, and Xin Jin, “Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPAR alpha/LPL an,” Plos One, vol. 10, no. 7, 2015. View at Publisher · View at Google Scholar
  • Davorka Messmer, Nicholas Chiorazzi, Xiao Jie Yan, David Spaner, Peppi Prasit, Daniel Lorrain, Kymmy Lorrain, Karin Stebbins, Yalda Bravo, Nicholas Stock, Geraldine Cabrera, Lucia Correa, Austin Chen, and Jason Jacintho, “A selective novel peroxisome proliferator–activated receptor (PPAR)-α antagonist induces apoptosis and inhibits proliferation of CLL cells in vitro and in vivo,” Molecular Medicine, vol. 21, pp. 410–419, 2015. View at Publisher · View at Google Scholar
  • Karolin Weitkunat, Sara Schumann, Klaus Jürgen Petzke, Michael Blaut, Gunnar Loh, and Susanne Klaus, “Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice,” The Journal of Nutritional Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Stanley M.H. Chan, Xiao-Yi Zeng, Ruo-Qiong Sun, Eunjung Jo, Xiu Zhou, Hao Wang, Songpei Li, Aimin Xu, Matthew J. Watt, and Ji-Ming Ye, “Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015. View at Publisher · View at Google Scholar
  • Yanchang Wei, Cai-Rong Yang, Yan-Ping Wei, Zhao-Jia Ge, Zhen-Ao Zhao, Bing Zhang, Yi Hou, Heide Schatten, and Qing-Yuan Sun, “Enriched Environment-induced Maternal Weight Loss Reprograms Metabolic Gene Expression in Mouse Offspring,” Journal Of Biological Chemistry, vol. 290, no. 8, pp. 4604–4619, 2015. View at Publisher · View at Google Scholar
  • Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M. Aleksunes, Curtis Klaassen, and J. Christopher Corton, “Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) in a Mouse Liver Gene Expression Co,” Plos One, vol. 10, no. 2, 2015. View at Publisher · View at Google Scholar
  • Chise Tateno, Toshinobu Yamamoto, Rie Utoh, Chihiro Yamasaki, Yuji Ishida, Yuka Myoken, Ken Oofusa, Miyoko Okada, Naohisa Tsutsui, and Katsutoshi Yoshizato, “Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha,” Toxicologic Pathology, vol. 43, no. 2, pp. 233–248, 2015. View at Publisher · View at Google Scholar
  • Diana M. Shih, Zeneng Wang, Richard Lee, Yonghong Meng, Nam Che, Sarada Charugundla, Hannah Qi, Judy Wu, Calvin Pan, J. Mark Brown, Thomas Vallim, Brian J. Bennett, Mark Graham, Stanley L. Hazen, and Aldons J. Lusis, “Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis,” Journal Of Lipid Research, vol. 56, no. 1, pp. 22–37, 2015. View at Publisher · View at Google Scholar
  • Maísa Silva, Joyce Ferreira da Costa Guerra, Ana Flávia Santos Sampaio, Wanderson Geraldo de Lima, Marcelo Eustáquio Silva, and Maria Lucia Pedrosa, “Iron Dextran Increases Hepatic Oxidative Stress and Alters Expression of Genes Related to Lipid Metabolism Contributing to Hyperlipidaemia in Murine Model,” BioMed Research International, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Soumen K. Manna, Matthew D. Thompson, Frank J. Gonzalez, Soumen K. Manna, Matthew D. Thompson, and Frank J. Gonzalez, “Application of Mass Spectrometry-Based Metabolomics in Identification of Early Noninvasive Biomarkers of Alcohol-Induced Liver Disease Using Mouse Mod,” Biological Basis Of Alcohol-Induced Cancer, vol. 815, pp. 217–238, 2015. View at Publisher · View at Google Scholar
  • Minako Karahashi, Yuko Hirata-Hanta, Kohei Kawabata, Daisuke Tsutsumi, Misaki Kametani, Nanako Takamatsu, Takeshi Sakamoto, Tohru Yamazaki, Satoshi Asano, Atsushi Mitsumoto, Yoichi Kawashima, and Naomi Kudo, “Abnormalities in the Metabolism of Fatty Acids and Triacylglycerols in the Liver of the Goto-Kakizaki Rat: A Model for Non-Obese Type 2 Diabetes,” Lipids, 2016. View at Publisher · View at Google Scholar
  • G. Kühn, K. Pallauf, J. García, J. Segura, I. Ipharraguerre, A. Mereu, I. Stubhaug, W. Koppe, G. Rimbach, and D. Menoyo, “ Effect of diets low in fish oil and supplemented with chlorogenic acid on fatty acid composition and lipid metabolism in Atlantic salmon ( Salmo salar L.) ,” Aquaculture Nutrition, 2016. View at Publisher · View at Google Scholar
  • Yun Zhang, Hongli Guo, Hozeifa M. Hassan, Ping-ping Ding, Yijing Su, Yuming Song, Tao Wang, Lixin Sun, Luyong Zhang, and Zhenzhou Jiang, “Pyrazinamide induced hepatic injury in rats through inhibiting the PPARα pathway,” Journal of Applied Toxicology, 2016. View at Publisher · View at Google Scholar
  • I. Miller, T. Serchi, S. Cambier, C. Diepenbroek, J. Renaut, J.H.J. Van der Berg, C. Kwadijk, A.C. Gutleb, E. Rijntjes, and A.J. Murk, “Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats,” Toxicology Letters, vol. 245, pp. 40–51, 2016. View at Publisher · View at Google Scholar
  • Ingrid T.G.W. Bijsmans, Alexandra Milona, Noortje Ijssennagger, Ellen C.L. Willemsen, José M. Ramos Pittol, Johan W. Jonker, Katja Lange, Guido J.E.J. Hooiveld, and Saskia W.C. van Mil, “Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016. View at Publisher · View at Google Scholar
  • Pramod R. Somvanshi, Anilkumar K. Patel, Sharad Bhartiya, and K. V. Venkatesh, “Influence of plasma macronutrient levels on hepatic metabolism: role of regulatory networks in homeostasis and disease states,” RSC Adv., vol. 6, no. 17, pp. 14344–14371, 2016. View at Publisher · View at Google Scholar
  • Rudolf Zechner, Frank Madeo, and Dagmar Kratky, “Cytosolic lipolysis and lipophagy: two sides of the same coin,” Nature Reviews Molecular Cell Biology, 2017. View at Publisher · View at Google Scholar
  • Yun-feng Lu, Ji-bao Chen, Bo Zhang, Qing-gang Li, Zhi-xiu Wang, Hao Zhang, and Ke-liang Wu, “Cloning, expression, and polymorphism of the ECI1 gene in various pig breeds,” Journal of Integrative Agriculture, vol. 16, no. 8, pp. 1789–1799, 2017. View at Publisher · View at Google Scholar
  • Afshin Hosseini, Mustafa Salman, Zheng Zhou, James K. Drackley, Erminio Trevisi, and Juan J. Loor, “Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows,” Journal of Animal Science and Biotechnology, vol. 8, no. 1, 2017. View at Publisher · View at Google Scholar
  • Robert W. Buntyn, Navatha Alugubelly, Rachel L. Hybart, Afzaal N. Mohammed, Carole A. Nail, Greta C. Parker, Matthew K. Ross, and Russell L. Carr, “Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats,” International Journal of Toxicology, pp. 109158181772527, 2017. View at Publisher · View at Google Scholar
  • Maria Schindler, Mareike Pendzialek, Bernd Fischer, Katarzyna Joanna Grybel, Tom Seeling, Jacqueline Gürke, and Anne Navarrete Santos, “Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts,” Human Reproduction, vol. 32, no. 7, pp. 1382–1392, 2017. View at Publisher · View at Google Scholar
  • Montserrat A. de la Rosa Rodriguez, and Sander Kersten, “Regulation of Lipid Droplet-Associated Proteins by Peroxisome Proliferator-Activated Receptors,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017. View at Publisher · View at Google Scholar
  • Mitchell B. Rosen, Kaberi P. Das, John Rooney, Barbara Abbott, Christopher Lau, and J. Christopher Corton, “PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling,” Toxicology, 2017. View at Publisher · View at Google Scholar
  • Qian Wang, Hongkai Yan, Gang Wang, Zhaoyan Qiu, Bin Bai, Shiqi Wang, Pengfei Yu, Quanxin Feng, Qingchuan Zhao, Xianli He, and Chaoxu Liu, “RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Terry D. Hinds, Peter A. Hosick, Shujuan Chen, Robert H. Tukey, Michael W. Hankins, Andrea Nestor-Kalinoski, and David E. Stec, “Mice with hyperbilirubinemia due to Gilbert’s syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα,” American Journal of Physiology - Endocrinology and Metabolism, vol. 312, no. 4, pp. E244–E252, 2017. View at Publisher · View at Google Scholar
  • J. G. Wang, Y. Z. Guo, Y. Z. Kong, S. Dai, and B. Y. Zhao, “High non-esterified fatty acid concentrations promote expression and secretion of fibroblast growth factor 21 in calf hepatocytes cultured in vitro,” Journal of Animal Physiology and Animal Nutrition, 2017. View at Publisher · View at Google Scholar
  • Caroline E Geisler, and Benjamin J Renquist, “Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones,” Journal of Endocrinology, vol. 234, no. 1, pp. R1–R21, 2017. View at Publisher · View at Google Scholar
  • Yan Lu, and Hope D. Anderson, “Cannabinoid signaling in health and disease,” Canadian Journal of Physiology and Pharmacology, pp. 1–17, 2017. View at Publisher · View at Google Scholar
  • Nicola Morrice, George D. Mcilroy, Seshu R. Tammireddy, Jennifer Reekie, Kirsty D. Shearer, Mary K. Doherty, Mirela Delibegović, Phillip D. Whitfield, and Nimesh Mody, “Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice,” Scientific Reports, vol. 7, pp. 43782, 2017. View at Publisher · View at Google Scholar
  • Fenni Rusli, Carolien Lute, Mark V. Boekschoten, Miriam van Dijk, Klaske van Norren, Aswin L. Menke, Michael Müller, and Wilma T. Steegenga, “Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice,” Molecular Nutrition & Food Research, pp. 1600677, 2017. View at Publisher · View at Google Scholar
  • Gernot F. Grabner, Robert Zimmermann, Rudolf Schicho, and Ulrike Taschler, “Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling,” Pharmacology & Therapeutics, 2017. View at Publisher · View at Google Scholar
  • Hong Zhong, Ke Chen, Mengyang Feng, Wei Shao, Jun Wu, Kun Chen, Tingming Liang, and Chang Liu, “Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis,” The FEBS Journal, 2017. View at Publisher · View at Google Scholar
  • Ali Saeed, Robin Dullaart, Tim Schreuder, Hans Blokzijl, and Klaas Faber, “Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD),” Nutrients, vol. 10, no. 1, pp. 29, 2017. View at Publisher · View at Google Scholar
  • Chun-Chung Wang, Jui-Hung Yen, Yi-Cheng Cheng, Chia-Yu Lin, Cheng-Ta Hsieh, Rung-Jiun Gau, Shu-Jiau Chiou, and Hwan-You Chang, “ Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles ,” Food & Nutrition Research, vol. 61, no. 1, pp. 1379861, 2017. View at Publisher · View at Google Scholar
  • Sander Kersten, and Rinke Stienstra, “The Role and Regulation of the Peroxisome Proliferator Activated Receptor alpha in Human Liver,” Biochimie, 2017. View at Publisher · View at Google Scholar
  • Mate Maus, Mario Cuk, Bindi Patel, Jayson Lian, Mireille Ouimet, Ulrike Kaufmann, Jun Yang, Rita Horvath, Hue-Tran Hornig-Do, Zofia M. Chrzanowska-Lightowlers, Kathryn J. Moore, Ana Maria Cuervo, and Stefan Feske, “Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism,” Cell Metabolism, 2017. View at Publisher · View at Google Scholar
  • Meng Zhao, Yan Zhang, Yichi Xu, Haifang Wang, Zhihu Zhao, Zenghua Fan, Jun Yan, Parth D. Joshi, Ping Li, and Weimin Guo, “A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation,” Nucleic Acids Research, vol. 45, no. 10, pp. 5720–5738, 2017. View at Publisher · View at Google Scholar
  • Ariel D. Quiroga, and Richard Lehner, “Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly,” Biochemical Pharmacology, vol. 155, pp. 233–241, 2018. View at Publisher · View at Google Scholar
  • Jianguo Wang, Xiaoyan Zhu, Guanghui She, Yezi Kong, Yazhou Guo, Zhe Wang, Guowen Liu, and Baoyu Zhao, “Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders,” BMC Veterinary Research, vol. 14, no. 1, 2018. View at Publisher · View at Google Scholar
  • Nadia Bougarne, Basiel Weyers, Sofie J Desmet, Julie Deckers, David W Ray, Bart Staels, and Karolien De Bosscher, “Molecular Actions of PPARα in Lipid Metabolism and Inflammation,” Endocrine Reviews, vol. 39, no. 5, pp. 760–802, 2018. View at Publisher · View at Google Scholar
  • Junco S. Warren, Christopher M. Tracy, Mickey R. Miller, Aman Makaju, Marta W. Szulik, Shin-ichi Oka, Tatiana N. Yuzyuk, James E. Cox, Anil Kumar, Bucky K. Lozier, Li Wang, June García Llana, Amira D. Sabry, Keiko M. Cawley, Dane W. Barton, Yong Hwan Han, Sihem Boudina, Oliver Fiehn, Haley O. Tucker, Alexey V. Zaitsev, and Sarah Franklin, “Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart,” Proceedings of the National Academy of Sciences, pp. 201800680, 2018. View at Publisher · View at Google Scholar
  • Tânia Vieira Madureira, Fernanda Malhão, Tiago Simões, Ivone Pinheiro, Célia Lopes, José F. Gonçalves, Ralph Urbatzka, L. Filipe C. Castro, Marco F.L. Lemos, and Eduardo Rocha, “Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and peroxisome signaling — Molecular, biochemical and morphological insights,” Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol. 212, pp. 1–17, 2018. View at Publisher · View at Google Scholar