Peroxisome Proliferator-Activated Receptors and Acute Lung Injury

Di Paola, Rosanna; Cuzzocrea, Salvatore

doi:https://doi.org/10.1155/2007/63745

PPAR Research

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PPARs in Lung Biology and Disease

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Review Article | Open Access

Volume 2007 | Article ID 063745 | https://doi.org/10.1155/2007/63745

Peroxisome Proliferator-Activated Receptors and Acute Lung Injury

Rosanna Di Paola^1,2and Salvatore Cuzzocrea^1,2

Academic Editor: Jesse Roman

Received22 Dec 2006

Revised08 Feb 2007

Accepted02 May 2007

Published08 Jul 2007

Abstract

Peroxisome proliferator-activated receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARs regulate several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid biosynthesis and glucose metabolism. Recently, PPARs and their respective ligands have been implicated as regulators of cellular inflammatory and immune responses. These molecules are thought to exert anti-inflammatory effects by negatively regulating the expression of proinflammatory genes. Several studies have demonstrated that PPAR ligands possess anti-inflammatory properties and that these properties may prove helpful in the treatment of inflammatory diseases of the lung. This review will outline the anti-inflammatory effects of PPARs and PPAR ligands and discuss their potential therapeutic effects in animal models of inflammatory lung disease.

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Copyright

Copyright © 2007 Rosanna Di Paola and Salvatore Cuzzocrea. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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