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PPAR Research
Volume 2007, Article ID 68202, 7 pages
http://dx.doi.org/10.1155/2007/68202
Review Article

PPARs and Adipose Cell Plasticity

1IFR 31, Institut Louis Bugnard, CNRS/UPS UMR 5241, Toulouse Cedex 4 31432, France
2Laboratorio de Diabetes y Obesidad Experimentales, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Villarroel, 170, Barcelona 08036, Spain

Received 28 February 2007; Accepted 18 April 2007

Academic Editor: Jeffrey M. Gimble

Copyright © 2007 Louis Casteilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Ellenbogen, “Free autogenous pearl fat grafts in the face—a preliminary report of a rediscovered technique,” Annals of Plastic Surgery, vol. 16, no. 3, pp. 179–194, 1986.
  2. T. A. Moseley, M. Zhu, and M. H. Hedrick, “Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery,” Plastic and Reconstructive Surgery, vol. 118, no. 3 supplement, pp. 121S–128S, 2006. View at Publisher · View at Google Scholar · View at PubMed
  3. M. S. Stosich and J. J. Mao, “Adipose tissue engineering from human adult stem cells: clinical implications in plastic and reconstructive surgery,” Plastic and Reconstructive Surgery, vol. 119, no. 1, pp. 71–83, 2007. View at Publisher · View at Google Scholar · View at PubMed
  4. G. Ailhaud, P. Grimaldi, and R. Négrel, “Cellular and molecular aspects of adipose tissue development,” Annual Review of Nutrition, vol. 12, pp. 207–233, 1992. View at Publisher · View at Google Scholar · View at PubMed
  5. J. M. Gimble, “The function of adipocytes in the bone marrow stroma,” New Biologist, vol. 2, no. 4, pp. 304–312, 1990.
  6. J. Himms-Hagen, “Brown adipose tissue thermogenesis: interdisciplinary studies,” FASEB Journal, vol. 4, no. 11, pp. 2890–2898, 1990.
  7. G. Ailhaud, “Adipose tissue as an endocrine organ,” International Journal of Obesity and Related Metabolic Disorders, vol. 24, supplement 2, pp. S1–S3, 2000.
  8. S. Klaus, L. Casteilla, F. Bouillaud, and D. Ricquier, “The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue,” International Journal of Biochemistry, vol. 23, no. 9, pp. 791–801, 1991. View at Publisher · View at Google Scholar
  9. D. G. Nicholls and R. M. Locke, “Thermogenic mechanisms in brown fat,” Physiological Reviews, vol. 64, no. 1, pp. 1–64, 1984.
  10. B. Prunet-Marcassus, B. Cousin, D. Caton, M. André, L. Pénicaud, and L. Casteilla, “From heterogeneity to plasticity in adipose tissues: site-specific differences,” Experimental Cell Research, vol. 312, no. 6, pp. 727–736, 2006. View at Publisher · View at Google Scholar · View at PubMed
  11. S. Klaus and J. Keijer, “Gene expression profiling of adipose tissue: individual, depot-dependent, and sex-dependent variabilities,” Nutrition, vol. 20, no. 1, pp. 115–120, 2004. View at Publisher · View at Google Scholar
  12. B. L. Wajchenberg, “Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome,” Endocrine Reviews, vol. 21, no. 6, pp. 697–738, 2000. View at Publisher · View at Google Scholar
  13. D. L. Mackay, P. J. Tesar, L.-N. Liang, and S. E. Haynesworth, “Characterizing medullary and human mesenchymal stem cell-derived adipocytes,” Journal of Cellular Physiology, vol. 207, no. 3, pp. 722–728, 2006. View at Publisher · View at Google Scholar · View at PubMed
  14. S. Altiok, M. Xu, and B. M. Spiegelman, “PPARγ induces cell cycle withdrawal: inhibition of E2f/DP DNA-binding activity via down-regulation of PP2A,” Genes and Development, vol. 11, no. 15, pp. 1987–1998, 1997.
  15. L. Fajas, R. L. Landsberg, Y. Huss-Garcia, C. Sardet, J. A. Lees, and J. Auwerx, “E2Fs regulate adipocyte differentiation,” Developmental Cell, vol. 3, no. 1, pp. 39–49, 2002. View at Publisher · View at Google Scholar
  16. M. Classon, B. K. Kennedy, R. Mulloy, and E. Harlow, “Opposing roles of pRB and p107 in adipocyte differentiation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 20, pp. 10826–10831, 2000. View at Publisher · View at Google Scholar · View at PubMed
  17. P. Tontonoz, S. Singer, and B. M. Forman et al., “Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 1, pp. 237–241, 1997. View at Publisher · View at Google Scholar
  18. J.-R. Weng, C.-Y. Chen, J. J. Pinzone, M. D. Ringel, and C.-S. Chen, “Beyond peroxisome proliferator-activated receptor γ signaling: the multi-facets of the antitumor effect of thiazolidinediones,” Endocrine-Related Cancer, vol. 13, no. 2, pp. 401–413, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. K. Wada, A. Nakajima, and K. Katayama et al., “Peroxisome proliferator-activated receptor γ-mediated regulation of neural stem cell proliferation and differentiation,” Journal of Biological Chemistry, vol. 281, no. 18, pp. 12673–12681, 2006. View at Publisher · View at Google Scholar · View at PubMed
  20. B. M. Spiegelman, “PPAR-γ: adipogenic regulator and thiazolidinedione receptor,” Diabetes, vol. 47, no. 4, pp. 507–514, 1998. View at Publisher · View at Google Scholar
  21. B. M. Spiegelman, P. Puigserver, and Z. Wu, “Regulation of adipogenesis and energy balance by PPARγ and PGC-1,” International Journal of Obesity and Related Metabolic Disorders, vol. 24, supplement 4, pp. S8–S10, 2000.
  22. E. D. Rosen, “The transcriptional basis of adipocyte development,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 73, no. 1, pp. 31–34, 2005. View at Publisher · View at Google Scholar · View at PubMed
  23. D. Yoshiga, N. Sato, and T. Torisu et al., “Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor γ messenger ribonucleic acid levels,” Molecular Endocrinology, vol. 21, no. 5, pp. 1120–1131, 2007. View at Publisher · View at Google Scholar · View at PubMed
  24. A. Fredenrich and P. A. Grimaldi, “PPAR delta: an uncompletely known nuclear receptor,” Diabetes and Metabolism, vol. 31, no. 1, pp. 23–27, 2005. View at Publisher · View at Google Scholar
  25. R. M. Evans, G. D. Barish, and Y.-X. Wang, “PPARs and the complex journey to obesity,” Nature Medicine, vol. 10, no. 4, pp. 355–361, 2004. View at Publisher · View at Google Scholar · View at PubMed
  26. M. Carmona, K. Louche, and M. Nibbelink et al., “Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice,” International Journal of Obesity, vol. 29, no. 7, pp. 864–871, 2005. View at Publisher · View at Google Scholar · View at PubMed
  27. P. Li, Z. Zhu, Y. Lu, and J. G. Granneman, “Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-α,” American Journal of Physiology - Endocrinology and Metabolism, vol. 289, no. 4, pp. E617–E626, 2005. View at Publisher · View at Google Scholar · View at PubMed
  28. K. Matsusue, J. M. Peters, and F. J. Gonzalez, “PPARβ/δ potentiates PPARγ-stimulated adipocyte differentiation,” FASEB Journal, vol. 18, no. 12, pp. 1477–1479, 2004. View at Publisher · View at Google Scholar · View at PubMed
  29. Z. Yun, H. L. Maecker, R. S. Johnson, and A. J. Giaccia, “Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia,” Developmental Cell, vol. 2, no. 3, pp. 331–341, 2002. View at Publisher · View at Google Scholar
  30. M. Suzawa, I. Takada, and J. Yanagisawa et al., “Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade,” Nature Cell Biology, vol. 5, no. 3, pp. 224–230, 2003. View at Publisher · View at Google Scholar · View at PubMed
  31. Q. Tong, G. Dalgin, H. Xu, C.-N. Ting, J. M. Leiden, and G. S. Hotamisligil, “Function of GATA transcription factors in preadipocyte-adipocyte transition,” Science, vol. 290, no. 5489, pp. 134–138, 2000. View at Publisher · View at Google Scholar
  32. K. M. Hong, M. D. Burdick, R. J. Philips, D. Heber, and R. M. Strieter, “Characterization of human fibrocytes as circulating adipocyte progenitors and the formation of human adipose tissue in SCID mice,” FASEB Journal, vol. 19, no. 14, pp. 2029–2031, 2005. View at Publisher · View at Google Scholar · View at PubMed
  33. J. T. Crossno Jr., S. M. Majka, T. Grazia, R. G. Gill, and D. J. Klemm, “Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells,” Journal of Clinical Investigation, vol. 116, no. 12, pp. 3220–3228, 2006. View at Publisher · View at Google Scholar · View at PubMed
  34. B. Cousin, S. Cinti, and M. Morroni et al., “Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization,” Journal of Cell Science, vol. 103, part 4, pp. 931–942, 1992.
  35. N. Viguerie-Bascands, A. Bousquet-Mélou, and J. Galitzky et al., “Evidence for numerous brown adipocytes lacking functional β 3-adrenoceptors in fat pads from nonhuman primates,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 1, pp. 368–375, 1996. View at Publisher · View at Google Scholar
  36. S. Cinti, “The adipose organ,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 73, no. 1, pp. 9–15, 2005. View at Publisher · View at Google Scholar · View at PubMed
  37. L. Casteilla, J. Nouguès, Y. Reyne, and D. Ricquier, “Differentiation of ovine brown adipocyte precursor cells in a chemically defined serum-free medium. Importance of glucocorticoids and age of animals,” European Journal of Biochemistry, vol. 198, no. 1, pp. 195–199, 1991. View at Publisher · View at Google Scholar
  38. K. Moulin, N. Truel, and M. André et al., “Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype,” Biochemical Journal, vol. 356, part 2, pp. 659–664, 2001. View at Publisher · View at Google Scholar
  39. C. Dani, A. G. Smith, and S. Dessolin et al., “Differentiation of embryonic stem cells into adipocytes in vitro,” Journal of Cell Science, vol. 110, part 11, pp. 1279–1285, 1997.
  40. A. Valmaseda, M. Carmona, and M. J. Barberá et al., “Opposite regulation of PPAR-α and -γ gene expression by both their ligands and retinoic acid in brown adipocytes,” Molecular and Cellular Endocrinology, vol. 154, no. 1-2, pp. 101–109, 1999. View at Publisher · View at Google Scholar
  41. P. Puigserver, Z. Wu, C. W. Park, R. Graves, M. Wright, and B. M. Spiegelman, “A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis,” Cell, vol. 92, no. 6, pp. 829–839, 1998. View at Publisher · View at Google Scholar
  42. C. Tiraby, G. Tavernier, and C. Lefort et al., “Acquirement of brown fat cell features by human white adipocytes,” Journal of Biological Chemistry, vol. 278, no. 35, pp. 33370–33376, 2003. View at Publisher · View at Google Scholar · View at PubMed
  43. C. Handschin and B. M. Spiegelman, “Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism,” Endocrine Reviews, vol. 27, no. 7, pp. 728–735, 2006. View at Publisher · View at Google Scholar · View at PubMed
  44. J. B. Hansen, C. Jørgensen, and R. K. Petersen et al., “Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 12, pp. 4112–4117, 2004. View at Publisher · View at Google Scholar · View at PubMed
  45. M. Christian, E. Kiskinis, D. Debevec, G. Leonardsson, R. White, and M. G. Parker, “RIP140-targeted repression of gene expression in adipocytes,” Molecular and Cellular Biology, vol. 25, no. 21, pp. 9383–9391, 2005. View at Publisher · View at Google Scholar · View at PubMed
  46. L. Casteilla and C. Dani, “Adipose tissue-derived cells: from physiology to regenerative medicine,” Diabetes and Metabolism, vol. 32, no. 5, part 1, pp. 393–401, 2006. View at Publisher · View at Google Scholar
  47. J. M. Gimble and F. Guilak, “Adipose-derived adult stem cells: isolation, characterization, and differentiation potential,” Cytotherapy, vol. 5, no. 5, pp. 362–369, 2003. View at Publisher · View at Google Scholar · View at PubMed
  48. P. A. Zuk, M. Zhu, and P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002. View at Publisher · View at Google Scholar · View at PubMed
  49. K. Yamanouchi, A. Ban, S. Shibata, T. Hosoyama, Y. Murakami, and M. Nishihara, “Both PPARγ and C/EBPα are sufficient to induce transdifferentiation of goat fetal myoblasts into adipocytes,” 2007, to appear in Journal of Reproduction and Development.
  50. M. F. Pittenger, A. M. Mackay, and S. C. Beck et al., “Multilineage potential of adult human mesenchymal stem cells,” Science, vol. 284, no. 5411, pp. 143–147, 1999. View at Publisher · View at Google Scholar
  51. A.-M. Rodriguez, D. Pisani, and C. A. Dechesne et al., “Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse,” Journal of Experimental Medicine, vol. 201, no. 9, pp. 1397–1405, 2005. View at Publisher · View at Google Scholar · View at PubMed
  52. M. E. Nuttall and J. M. Gimble, “Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications,” Current Opinion in Pharmacology, vol. 4, no. 3, pp. 290–294, 2004. View at Publisher · View at Google Scholar · View at PubMed
  53. R. Z. Birk, L. Abramovitch-Gottlib, and I. Margalit et al., “Conversion of adipogenic to osteogenic phenotype using crystalline porous biomatrices of marine origin,” Tissue Engineering, vol. 12, no. 1, pp. 21–31, 2006. View at Publisher · View at Google Scholar · View at PubMed
  54. J. M. Gimble, S. Zvonic, Z. E. Floyd, M. Kassem, and M. E. Nuttall, “Playing with bone and fat,” Journal of Cellular Biochemistry, vol. 98, no. 2, pp. 251–266, 2006. View at Publisher · View at Google Scholar · View at PubMed
  55. S. W. Kim, S. J. Her, S. Y. Kim, and C. S. Shin, “Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts,” Biochemical and Biophysical Research Communications, vol. 327, no. 3, pp. 811–819, 2005. View at Publisher · View at Google Scholar · View at PubMed
  56. A. Yamashita, T. Takada, K. Nemoto, G. Yamamoto, and R. Torii, “Transient suppression of PPARγ directed ES cells into an osteoblastic lineage,” FEBS Letters, vol. 580, no. 17, pp. 4121–4125, 2006. View at Publisher · View at Google Scholar · View at PubMed
  57. G. Sabatakos, N. A. Sims, and J. Chen et al., “Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis,” Nature Medicine, vol. 6, no. 9, pp. 985–990, 2000. View at Publisher · View at Google Scholar · View at PubMed
  58. M. Kveiborg, G. Sabatakos, and R. Chiusaroli et al., “ΔFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms,” Molecular and Cellular Biology, vol. 24, no. 7, pp. 2820–2830, 2004. View at Publisher · View at Google Scholar
  59. J.-H. Hong, E. S. Hwang, and M. T. McManus et al., “TAZ, a transcriptional modulator of mesenchymal stem cell differentiation,” Science, vol. 309, no. 5737, pp. 1074–1078, 2005. View at Publisher · View at Google Scholar · View at PubMed
  60. E. Hu, P. Tontonoz, and B. M. Spiegelman, “Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 21, pp. 9856–9860, 1995. View at Publisher · View at Google Scholar
  61. D. Holst, S. Luquet, K. Kristiansen, and P. A. Grimaldi, “Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation,” Experimental Cell Research, vol. 288, no. 1, pp. 168–176, 2003. View at Publisher · View at Google Scholar
  62. S. E. Ross, N. Hemati, and K. A. Longo et al., “Inhibition of adipogenesis by Wnt signaling,” Science, vol. 289, no. 5481, pp. 950–953, 2000. View at Publisher · View at Google Scholar
  63. J. Liu and S. R. Farmer, “Regulating the balance between peroxisome proliferator-activated receptor γ and β-catenin signaling during adipogenesis: a glycogen synthase kinase 3β phosphorylation-defective mutant of β-catenin inhibits expression of a subset of adipogenic genes,” Journal of Biological Chemistry, vol. 279, no. 43, pp. 45020–45027, 2004. View at Publisher · View at Google Scholar · View at PubMed
  64. H. S. Kim, L. Liang, R. G. Dean, D. B. Hausman, D. L. Hartzell, and C. A. Baile, “Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures,” Biochemical and Biophysical Research Communications, vol. 281, no. 4, pp. 902–906, 2001. View at Publisher · View at Google Scholar · View at PubMed
  65. J. N. Artaza, S. Bhasin, and T. R. Magee et al., “Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells,” Endocrinology, vol. 146, no. 8, pp. 3547–3557, 2005. View at Publisher · View at Google Scholar · View at PubMed
  66. B. J. Feldman, R. S. Streeper, R. V. Farese Jr., and K. R. Yamamoto, “Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 42, pp. 15675–15680, 2006. View at Publisher · View at Google Scholar · View at PubMed
  67. B. Cousin, O. Munoz, and M. Andre et al., “A role for preadipocytes as macrophage-like cells,” FASEB Journal, vol. 13, no. 2, pp. 305–312, 1999.
  68. C. Saillan-Barreau, B. Cousin, M. André, P. Villena, L. Casteilla, and L. Pénicaud, “Human adipose cells as candidates in defense and tissue remodeling phenomena,” Biochemical and Biophysical Research Communications, vol. 309, no. 3, pp. 502–505, 2003. View at Publisher · View at Google Scholar
  69. G. Charrière, B. Cousin, and E. Arnaud et al., “Preadipocyte conversion to macrophage: evidence of plasticity,” Journal of Biological Chemistry, vol. 278, no. 11, pp. 9850–9855, 2003. View at Publisher · View at Google Scholar · View at PubMed
  70. H. Xu, G. T. Barnes, and Q. Yang et al., “Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1821–1830, 2003. View at Publisher · View at Google Scholar · View at PubMed
  71. R. Walczak and P. Tontonoz, “PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism,” Journal of Lipid Research, vol. 43, no. 2, pp. 177–186, 2002.
  72. K. J. Moore, E. D. Rosen, and M. L. Fitzgerald et al., “The role of PPAR-γ in macrophage differentiation and cholesterol uptake,” Nature Medicine, vol. 7, no. 1, pp. 41–47, 2001. View at Publisher · View at Google Scholar · View at PubMed
  73. M. Ricote, A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass, “The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation,” Nature, vol. 391, no. 6662, pp. 79–82, 1998. View at Publisher · View at Google Scholar · View at PubMed
  74. A. C. Li, C. J. Binder, and A. Gutierrez et al., “Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ,” Journal of Clinical Investigation, vol. 114, no. 11, pp. 1564–1576, 2004. View at Publisher · View at Google Scholar · View at PubMed
  75. H.-J. Lim, S. Lee, and K.-S. Lee et al., “PPARγ activation induces CD36 expression and stimulates foam cell like changes in rVSMCs,” Prostaglandins and Other Lipid Mediators, vol. 80, no. 3-4, pp. 165–174, 2006. View at Publisher · View at Google Scholar · View at PubMed