Synergistic Effects of PPAR Ligands and Retinoids in Cancer Treatment
Figure 1
PPAR activation
pathway and transcriptional regulation of target genes. After ligand binding, PPARs form heterodimers
with RXR in the nucleus. The PPAR/RXR
heterodimers interact with transcriptional coactivators (CoActs) and bind to
sequence specific PPRE located in the target genes that control glucose and
insulin homeostasis, lipid metabolism, inflammation, and cellular
differentiation. L: ligand.