Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer Pathogenesis

Figure 1

Domain structure of PPAR𝛿 and truncated forms of the receptor. AF-1, N-terminal ligand-independent activation function 1 (aa 1–70). DBD, DNA binding domain (aa 71–136). Hinge, flexible hinge region (aa 137–167). LBD, ligand-binding domain (aa 168–431). AF-2, C-terminal ligand-dependent activation function-2 (aa 432–441). The position of the mutations (K204R, K224R, and K229R) introduced in the region 204–235 is shown.