Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer Pathogenesis

Figure 3

Interactions between PPARs and the ubiquitin-proteasome system (UPS) affect multiple cellular pathways. The UPS regulates activity of PPARs by controlling receptor turnover in ligand dependent and independent manners and affecting the ability of PPARs to regulate target gene transcription. Signaling pathways can modulate PPAR activity by affecting UPS-mediated turnover (e.g., increased PPAR𝛾 degradation in response to growth factors or hormones). PPAR can also affect biological pathways and cellular responses by increasing or decreasing susceptibility of proteins to proteasomal degradation (e.g., enhanced degradation of 𝛽-catenin and suppression of the Wnt pathway by PPAR𝛾).