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PPAR Research
Volume 2008, Article ID 243791, 19 pages
http://dx.doi.org/10.1155/2008/243791
Review Article

PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility

Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, South Australia 5005, Australia

Received 2 April 2007; Accepted 2 July 2007

Academic Editor: Pascal Froment

Copyright © 2008 Cadence E. Minge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor gamma (PPARG) regulates cellular functions such as adipogenesis and immune cell activation. However, new information has indicated additional roles of PPARG directing the cyclic changes that occur within ovarian tissue of female mammals, including those that facilitate the release of oocytes each estrous cycle. In addition to ovarian PPARG expression and function, many PPARG actions within adipocytes and macrophages have additional direct and indirect implications for ovarian function and female fertility. This encompasses the regulation of lipid uptake and transport, insulin sensitivity, glucose metabolism, and the regulation of inflammatory mediator synthesis and release. This review discusses the developing links between PPARG activity and female reproductive function, and highlights several mechanisms that may facilitate such a relationship.