PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
Figure 2
(a) The genomic structure of the end of the human PPARG gene. Exons 1-6 are common. Exons A1
and A2 are untranslated, and exon B is translated, giving rise to two different
proteins corresponding to the G1 or G2 transcripts. (b) The domain structure of
PPARG1 and G2 isoforms with the positioning of mutations or polymorphisms
resulting in substituted amino acid residues, and altered protein functions.
DBD, DNA-binding domain; LBD, Ligand-binding domain. (Figure adapted from
Sundvold and Lien[33], Tsai and Maeda [37], and Stumvoll and Häring [38]).
