Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland

Table 1

Characteristics of study sample by gender, N = 9364, P value derived from χ2 test for categorical variables, Student’s t-test for continuous variables.

	Female N = 5776 (%)	Male N = 3588 (%)	Total (%)	P value
Age, mean(SD)	53.2 (15.4)	52.9 (15.5)	53.1 (15.4)	.3974
Education				.0029
<12	24.5	25.0	24.7
12	47.3	44.0	46.0
>12	28.2	31.0	29.3
Missing, n	4	1	5
BMI, kg/m^2, mean (SD)	26.1 (5.3)	26.6 (4.0)	26.3 (4.9)	<.0001
BMI, kg/m^2				<.0001
<25	48.8	34.0	43.1
25–30	30.8	48.8	37.7
>30	20.4	17.3	19.2
Missing, n	11	1	12
Smoking status				<.0001
Never	62.5	40.3	54.0
Former	21.4	42.7	29.6
Current	16.1	17.0	16.4
Missing, n			0
Cholesterol no Rx, mg/dL				<.0001
≤200	41.3	48.2	43.9
200–239	37.1	36.9	37.0
≥240	21.6	14.9	19.1
Cholesterol with Rx, mg/dL				<.0001
≤200	15.7	36.0	23.1
200–239	43.9	36.5	41.2
≥240	40.4	27.5	35.7
Blood pressure				<.0001
Normal	30.2	15.6	24.6
Prehypertensive	56.4	67.6	60.7
Hypertensive	13.4	16.8	14.7
Missing, n	5	6	11
PPARG rs4684847				.0910
CC	78.8	77.3	78.2
CT/TT	21.2	22.7	21.8
Missing, n	188	120	308
PPARG rs709158				.4741
AA	39.6	40.3	39.8
AG/GG	60.4	59.7	60.2
Missing, n	134	98	232
PPARG rs1175543				.9218
AA	40.2	40.1	40.2
AG/GG	59.8	59.9	59.8
Missing, n	136	91	227
PPARD rs2016520				.5240
CC	64.6	64.0	64.4
CT/TT	35.4	36.0	35.6
Missing, n	146	104	250
PPARG rs1801282				.2728
Pro/Pro	78.4	77.5	78.1
Pro/Ala or Ala/Ala	21.6	22.5	21.9
Missing, n	156	106	262