Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland

Table 3

Age-adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) of all-cause and cardiovascular mortality and nonfatal cardiovascular events for 5 PPAR polymorphisms. Person years: cumulative person years of follow up. RR (95% CI): relative risk using poisson regression.

		All-cause death		CV-related death		Nonfatal CV events		Fatal and nonfatal CV events
SNPs	Person years	n	HR (95% CI)	n	HR (95% CI)	n	RR (95% CI)	RR (95% CI)
PPARG rs4684847
CC	92827	1705	1.00 (reference)	416	1.00 (reference)	2351	1.00 (reference)	1.00 (reference)
CT/TT	25880	474	0.95 (0.85–1.05)	114	0.90 (0.73–1.11)	679	1.00 (0.73–1.37)	0.88 (0.67–1.18)
PPARG rs709158
AA	47812	850	1.00 (reference)	205	1.00 (reference)	1202	1.00 (reference)	1.00 (reference)
AG/GG	71972	1328	0.99 (0.91–1.09)	324	1.02 (0.86–1.20)	1843	0.98 (0.75–1.28)	0.98 (0.77–1.24)
PPARG rs1175543
AA	48172	867	1.00 (reference)	213	1.00 (reference)	1183	1.00 (reference)	1.00 (reference)
AG/GG	71627	1331	1.0 (0.92–1.09)	316	0.99 (0.83–1.18)	1864	1.03 (0.79–1.34)	1.00 (0.79–1.28)
PPARD rs2016520
CC	77042	1386	1.00 (reference)	342	1.00 (reference)	2027	1.00 (reference)	1.00 (reference)
CT/TT	42593	766	1.03 (0.94–1.12)	178	1.02 (0.85–1.23)	1003	0.91 (0.69–1.19)	0.98 (0.76–1.26)
PPARG rs1801282
Pro/Pro	93254	1696	1.00 (reference)	408	1.00 (reference)	2350	1.00 (reference)	1.00 (reference)
Pro/Ala or Ala/Ala	26196	456	0.96 (0.86–1.06)	112	0.97 (0.79–1.20)	656	0.98 (0.71–1.35)	0.96 (0.72–1.28)