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PPAR Research
Volume 2008, Article ID 293538, 6 pages
http://dx.doi.org/10.1155/2008/293538
Review Article

PPAR/-Independent Effects of PPAR/ Ligands on Cysteinyl Leukotriene Production in Mast Cells

Laboratory of Food Science, Department of Bioresource Science, Nihon University Junior College, 1866 Kameino, Fujisawa 252-8510, Japan

Received 3 March 2008; Revised 5 June 2008; Accepted 15 September 2008

Academic Editor: Francine M. Gregoire

Copyright © 2008 Masamichi Yamashita. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor (PPAR) ligands (Wy-14,643, and fenofibrate) and PPAR ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells. The inhibitory effect of these ligands on cysteinyl leukotriene production is quite strong and is almost equivalent to that of the anti-asthma compound zileuton. To develop new aspects for anti-asthma drugs the pharmacological target of these compounds should be clarified. Experiments with bone-marrow-derived mast cells from PPAR knockout mice and pharmacological inhibitors of PPAR suggest that the inhibitory effects of these ligands are independent of PPARs and . The mechanisms of the PPAR-independent inhibition by these agents on cysteinyl leukotriene production are discussed in this review.