Statins Activate Human PPAR Promoter and Increase PPAR mRNA Expression and Activation in HepG2 Cells
The transcriptional activity of PPAR in HepG2 cells transfected with human acyl-CoA oxidase (AOX) promoter-reporter plasmid after treatment with fenofibric acid (FA) and statins
for 24 hours. (a) FA was used at doses of 1, 10, 50, and . Nontreated cells (FA concentration ) were the control. (b) Atorvastatin (Ator),
cerivastatin (Ceri), fluvastatin (Flu), pitavastatin (Pita), pravastatin (Pra),
rosuvastatin (Rosu), and simvastatin (Sim) for 24 hours. Each statin was used
at doses of 1, 10, 25, and . Nontreated cells (statin concentration ) were the control. The data are expressed as
% of control. Values are presented as the mean SEM of three separate experiments, significantly
different from control at , .
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