Statins Activate Human PPAR Promoter and Increase PPAR mRNA Expression and Activation in HepG2 Cells
Figure 6
The Western blots represent HNF-4 levels in nuclear fractions of HepG2 cells
after treatment with atorvastatin (Ator), cerivastatin (Ceri), fluvastatin
(Flu), pitavastatin (Pita), pravastatin (Pra), rosuvastatin (Rosu), and
simvastatin (Sim) for 24 hours. Each statin was used at doses of 10 (a) or 25
(b) . Nontreated cells (statin concentration ) were the control. HNF-4 protein levels were quantified with an imaging
analyzer. The data are expressed as % of control. Values are presented as the
mean SEM of three separate
experiments, significantly different from control at , .