Hexarelin Signaling to PPAR𝛾 in Metabolic Diseases

Figure 1

A GHRP-PPAR 𝛾pathway in macrophages. Overview of the effects of hexarelin which by interacting with scavenger receptor CD36 and GHS-R1a ghrelin receptor promotes the transcriptional activation of PPAR𝛾. LXR𝛼 which is a target of PPAR𝛾 is then upregulated with the subsequent increase in apolipoprotein E (apoE) and sterol transporters ABCA1 and ABCG1 expression. Activation of the PPAR𝛾-LXR𝛼-ABC metabolic pathway in response to hexarelin favors cholesterol efflux by macrophages through high density lipoproteins (HDLs). Adapted from [52].