Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- Agonist
Figure 2
PPAR-γ activation by (a) MBX-102 acid, (b)
rosiglitazone, and (c) pioglitazone in the presence of increasing human
serum. Normalized reporter assay data were
calculated as the percentage of maximum signal by expressing each data point as
a percentage of the mean for the maximum signal. The percentage of maximum
signal for the curves representing 0%, 2%, 10%, and 20% (v/v) serum was
calculated independently. The dose-response curves shown are from a
representative experiment. Values are EC50 (M) determined from 3 experiments
and shown as the mean ± SD.
