Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-𝛾 Agonist

Table 2

Binding of MBX-102 acid to rat, mouse, and human albumin determined by plasmon resonance-based biosensors. The binding constants for the high-affinity site were determined at 37^°C. Values represent the mean of duplicate determinations (HSA: human serum albumin, MSA: mouse serum albumin, RSA: rat serum albumin).

Interaction	KD (𝜇M)	%Bound
HSA:MBX-102	5.8	99.1
MSA:MBX-102	5.5	99.2
RSA:MBX-102	12.8	98.1