Research Article

Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- 𝛾 Agonist

Table 3

Interspecies free MBX-102 acid ratios determined by competitive equilibrium dialysis. [3H] MBX-102 acid distribution between either mouse and human plasma or rat and human plasma was conducted by competitive equilibrium dialysis at 37°C. Values represent mean ± SD for 5 independent experiments.

MBX-102 Acid ( M) Free Fraction Ratio ( = 5 ± SD)
Rat:Human Mouse:Human

100
300
700
1000
1300