PPAR Ligands for Cancer Chemoprevention

Table 2

Effects of PPAR ligands on colon carcinogenesis in mice.

Treatment (no. of mice)	Incidence/Multiplicity (% inhibition)
	Total	Adenoma	Adenocarcinoma
AOM/DSS	100%/5.2±3.0^(a)	100%/2.1±1.8	100%/3.0±1.8
AOM/DSS/0.05% Troglitazone	90%/2.5±1.8^(b)(52%,)	90%/1.6±1.1 (24%)	40%^(c)/1.2±2.5^(b) (60%)
AOM/DSS/0.05% Bezafibrate	80%/2.6±2.5^(b)(50%)	70%/1.1±1.0^(b) (48%)	60%^(b)/1.8±2.6 (40%)
None	0%/0	0%/0	0%/0

^(a)Mean ±SD.
^(b,c)Significantly different from the AOM/DSS group: ^(b)P < .05; and ^(c)P < .01.