Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2008, Article ID 635680, 9 pages
http://dx.doi.org/10.1155/2008/635680
Review Article

Protective Actions of PPAR- Activation in Renal Endothelium

1Department of Vascular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
2Department of Internal Medicine, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands

Received 15 September 2008; Accepted 8 December 2008

Academic Editor: Nigel Brunskill

Copyright © 2008 Peter E. Westerweel and Marianne C. Verhaar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Renal endothelial damage is pivotal in the initiation and progression of renal disease. Damaged renal endothelium may be regenerated through proliferation of local endothelium and circulation-derived endothelial progenitor cells. Activation of the PPAR- -receptors present on endothelial cells affects their cellular behavior. Proliferation, apoptosis, migration, and angiogenesis by endothelial cells are modulated, but may involve both stimulation and inhibition depending on the specific circumstances. PPAR- -receptor activation stimulates the production of nitric oxide, C-type natriuretic peptide, and superoxide dismutase, while endothelin-1 production is inhibited. Together, they augment endothelial function, resulting in blood pressure lowering and direct renoprotective effects. The presentation of adhesion molecules and release of cytokines recruiting inflammatory cells are inhibited by PPAR- -agonism. Finally, PPAR- -receptors are also found on endothelial progenitor cells and PPAR- -agonists stimulate progenitor-mediated endothelial repair. Together, the stimulatory effects of PPAR- -agonism on endothelium make an important contribution to the beneficial actions of PPAR- -agonists on renal disease.