Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development
Figure 4
Real-time PCR data showing attenuation of the effect of DES on PPARγ
mRNA by ER blocker ICI 182, 780 in 28-day-old rats treated neonatally with
either 25 L of olive oil (CONT-28 d), oil containing DES (DES-28 d; 0.1 mg/kg
bw), or DES plus ICI (DES + ICI; 16.6 mg/kg). ICI treatment significantly
inhibited DES-induced PPARγ
mRNA [DES-28 d versus DES + ICI]. Comparison between control and DES treated rats
showed 7.1 fold increase in expression [CONT-28 d versus DES-28 d]. Letter [a] indicates no significant differences between
CONT-28 d and DES + ICI. Data () are expressed as mean ±SE. .
