The Role of the PAX8/PPAR𝛾 Fusion Oncogene in Thyroid Cancer

Figure 1

PAX8/PPAR𝛾 rearrangement illustrating the genomic structure with exon arrangement and sites of fusion. The PAX8 activation domain (AD) is eliminated in all fusion events. The protein structure of the predicted fusion protein is shown and contains the PAX8-paired domain, containing the DNA binding domain (DBD), the octapeptide motif (OP), and the truncated homeodomain (HD). All of the functional domains of PPAR𝛾 gene, including activation domains 1 and 2 (AD1 and AD2), DBD, and ligand binding domain are retained in the fusion protein.