The Role of the PAX8/PPAR𝛾 Fusion Oncogene in Thyroid Cancer

Table 1

Occurrence of PAX8/PPAR𝛾 rearrangements in differentiated thyroid carcinomas.

Author	Method	Benign nodular hyperplasia	Follicular adenoma	Follicular carcinoma	Hürthle cell carcinoma	Papillary carcinoma	Follicular variant of papillary	Anaplastic carcinoma
Kroll [3]	RT-PCR	0/10	0/20	5/8 (63%)	—	0/10	—	—
Martelli [14]	RT-PCR	—	—	0/5	—	0/41	—	0/5
Zhu [38]	RT-PCR	—	—	—	—	0/46	0/30	—
Nikiforova [39]	RT-PCR and nested PCR	0/16	2/25 (8%)	8/15 (53%)	0/12	0/23	0/12	0/2
Marques [36]	RT-PCR and nested PCR	0/2	2/16 (13%)	5/9 (56%)	—		0/9	0/4
Aldred [29]	RT-PCR	—	—	2/19 (11%)	—	—	—	—
Lacroix [40]	RT-PCR	—	1/16 (6%)	4/26 (15%)	0/4	—	—	0/5
Hibi [41]	RT-PCR	0/12	0/12	0/6	—	0/12	—	—
Marques [28]	RT-PCR and FISH	0/28	6/36 (17%)	6/24 (25%)	—	0/38	—	—
Sahin [42]	RT-PCR	—	4/31 (13%)	31/54 (57%)	1/23 (4%)	—	—	—
Nikiforova [43]	RT-PCR and FISH	—	1/23 (4%)	13/33 (36%)	0/19	—	—	—
Castro [44]	RT-PCR and FISH	—	—	—	—	—	4/8 (50%)	—
Cheung [37]	RT-PCR	—	6/11 (55%)	6/17 (35%)	—	—	—	—
Foukakis [45]	RT-PCR	—	1/8 (13%)	5/25 (20%)	—	—	—	—
Dwight [46]	RT-PCR, FISH and Western	—	1/40 (3%)	10/34 (29%)	—	—	—	0/13
Castro [47]	RT-PCR and FISH	—	3/9 (33.3%)	10/22 (45.5%)	—	0/2	9/24 (37.5%)	—
Giordano [48]	RT-PCR	—	—	7/13 (54%)	—	—	—	—
TOTAL		0/68	27/247 (11%)	112/310 (36%)	1/58 (2%)	0/172	13/83 (16%)	0/29