Review Article
Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template
Table 1
SAR 1: effect of the acidic partial structure
in the present series of compounds.
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(a) Compounds were screened for agonist
activity on PPAR-GAL4 chimeric receptors in transiently transfected CHO-K1
cells as described. EC50 value is
the molar concentration of the test compound that causes 50% of the maximal
reporter activity,(b) “ia” means inactive at the concentration of 10 M,(c) assayed as a racemate. |