Review Article
Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template
Table 4
In vitro functional PPAR transactivation activity of
substituted phenylpropanoic acids.
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(a)
Compounds were screened for agonist activity on PPAR-GAL4 chimeric receptors in
transiently transfected HEK-293 cells. The EC50 value is
the molar concentration of the test
compound that causes 50% of the maximal reporter activity,(b) “ia” means
inactive at the concentration of 10 M. |