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PPAR Research
Volume 2008, Article ID 723243, 8 pages
Review Article

PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice

Department of Physiology and Pathophysiology, Peking (Beijing) University Diabetes Center, Peking (Beijing) University Health Science Center, Beijing 100083, China

Received 1 July 2007; Accepted 6 December 2007

Academic Editor: Pascal Froment

Copyright © 2008 Jichun Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy homeostasis, inflammation, as well as cell proliferation and differentiation. In the past decade, intensive study of PPARs has shed novel insight into prevention and treatment of dyslipidemia, insulin resistance, and type 2 diabetes. Recently, a large body of research revealed that PPARs are also functionally expressed in reproductive organs and various parts of placenta during pregnancy, which strongly suggests that PPARs might play a critical role in reproduction and development, in addition to their central actions in energy homeostasis. In this review, we summarize recent findings elucidating the role of PPARs in female reproduction, with particular focus on evidence from gene knockout and transgenic animal model study.