Screening for PPAR Responsive Regulatory Modules in Cancer

Figure 1

Comparison of in silico and experimental analysis of PPAR target genes. Overview of the genomic organization of the UCP3 gene; 10 kB upstream and downstream of its TSS are shown (horizontal black line). Putative PPREs were identified using the classifier method performing in silico screening of the genomic sequences. For each predicted PPRE, the calculated binding strength of PPARγ is represented by column height. The average in vitro DNA binding strength of PPARγ-RXR heterodimers was also determined by gel shift experiments.