Combination Therapy of PPAR𝛾 Ligands and Inhibitors of Arachidonic Acid in Lung Cancer

Figure 1

Inflammatory products stimulate cPLA2α which increases levels of AA available to be metabolized by the LOX/COX pathways. LOX/COX enzymes’ products, leukotrienes and prostaglandins, induce cell proliferation. Natural ligands for PPARγ are also produced by the LOX/COX pathways. Activation of PPARγ balances the effect of leukotrienes and prostaglandins inducing apoptosis through various mechanisms. However, activation of PPARγ may also induce COX-2 and IL-8 expressions. Furthermore, overexpression of PPARγ may decrease invasion and induce differentiation from a mesenchymal to an epithelial-like phenotype.