The Role of PPAR Receptors and Leukotriene Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer
Figure 3
Effect of a PPARγ receptor antagonist, GW9662 on the inhibition of
proliferation induced by LY293111 in AsPC-1 human pancreatic cancer cells after
24 hours of treatment. These cells express both the PPARγ receptor and LTB4
(BLT1 and BLT2) receptors. While GW9662 alone was able to significantly
increase thymidine incorporation, it was not able to block the inhibitory
effect of different concentrations of LY293111.
