The Role of PPARs in the Endothelium: Implications for Cancer Therapy

Figure 3

Endothelial PPARγ has predominantly inhibitory actions on endothelial cell activation. The majority of studies so far indicate that PPARγ activation inhibits (broken line) proangiogenic factors, proinflammatory pathways, and procoagulant mediator release, while inducing (solid line) antiangiogenic factors.