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PPAR Research
Volume 2008, Article ID 931074, 7 pages
http://dx.doi.org/10.1155/2008/931074
Review Article

Peroxisome Proliferator-Activated Receptors and Progression of Colorectal Cancer

1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
2Departments of Gastrointestinal Oncology and Cancer Biology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030-4009, USA

Received 14 March 2008; Accepted 29 April 2008

Academic Editor: Dipak Panigrahy

Copyright © 2008 Dingzhi Wang and Raymond N. DuBois. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. These receptors are also ligand-dependent transcription factors responsible for the regulation of cellular events that range from glucose and lipid homeostases to cell differentiation and apoptosis. The importance of these receptors in lipid homeostasis and energy balance is well established. In addition to these metabolic and anti-inflammatory properties, emerging evidence indicates that PPARs can function as either tumor suppressors or accelerators, suggesting that these receptors are potential candidates as drug targets for cancer prevention and treatment. However, conflicting results have emerged regarding the role of PPARs on colon carcinogenesis. Therefore, further investigation is warranted prior to considering modulation of PPARs as an efficacious therapy for colorectal cancer chemoprevention and treatment.