The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer
Figure 1
Spectrum
of PPARγ effects. The range of biological activities, both desired antidiabetic therapeutic
effects and undesired effects related to tolerability and safety issues,
increases for ligands characterized as antagonists, selective agonists, full
agonists, and broad selectivity full agonists.